DOI: 10.1111/j.1349-7006.1991.tb01839.x. Macrophage–T Cell Interaction Is Essential for the Induction of p75 Interleukin 2 (IL–2) Receptor and IL–2 Responsiveness in Human CD4<sup>+</sup>T Cells

Macrophage–T Cell Interaction Is Essential for the Induction of p75 Interleukin 2 (IL–2) Receptor and IL–2 Responsiveness in Human CD4+T Cells

10.1111/j.1349-7006.1991.tb01839.x

Crossref journal-article

Wiley

Japanese Journal of Cancer Research (311)

Abstract

Fresh human CD8+T cells showed a strong proliferative response to a high concentration of interleukin 2 (IL–2) in the absence of macrophages. In contrast, CD4+T cells revealed no significant IL–2 responsiveness in the absence of macrophages. However, if CD4+T cells were cocultured with macrophages, they showed higher proliferative response to IL–2 than CD8+T cells. In accordance with the magnitude of IL–2 responsiveness, freshly isolated CD8+T cells expressed significant amounts of p75 IL–2 receptor, while fresh CD4+T cells did not express p75 IL–2 receptor. The expression of p75 IL–2 receptor on CD4+T cells was induced by coculture with macrophages. The macrophage–induced p75 IL–2 receptor acquisition was blocked by monoclonal antibody (inAh) against class II antigen. Moreover, the addition of anti–CD4 mAb or anti–class II mAb to the culture caused a great inhibition of IL–2 responsiveness of CD4+T cells. These results strongly suggest that macrophage–T cell interaction through CD4 and/or class II moleculesisessential for the expression of p75 IL–2 receptor and IL–2 responsiveness in human CD4+, but not CD8+T cells.

Bibliography

Nakamura, Y., Nishimura, T., Tokuda, Y., Kobayashi, N., Watanabe, K., Noto, T., Mitomi, T., Sugamura, K., & Habu, S. (1991). MacrophageâT Cell Interaction Is Essential for the Induction of p75 Interleukin 2 (ILâ2) Receptor and ILâ2 Responsiveness in Human CD4+T Cells. Japanese Journal of Cancer Research, 82(3), 257â261. Portico.

Authors 9

Yoshihiko Nakamura (first)
Takashi Nishimura (additional)
Yutaka Tokuda (additional)
Nobumasa Kobayashi (additional)
Katsuto Watanabe (additional)
Takashi Noto (additional)
Toshio Mitomi (additional)
Kazuo Sugamura (additional)
Sonoko Habu (additional)

References 17 Referenced 9

10.1084/jem.158.3.988
10.4049/jimmunol.134.1.330 / J. Immunol / Activation of human thymocytes via 50 KD Til sheep erythrocyte binding protein induces the expression of in–terleukin 2 receptors on both T3+ and T3− populations by Fox D. A. (1985)
10.1111/j.1600-065X.1980.tb00327.x
10.4049/jimmunol.126.4.1393 / J. Immunol / A monoclonal antibody (anti–Tac) reactive with activated and functionally mature human T cells. I. Production of anti–Tac monoclonal antibody and distribution of Tac (+) cells by Uchiyama T. (1981)
10.1084/jem.169.4.1323
10.1073/pnas.86.6.1982
10.1038/280239a0
10.1084/jem.170.4.1445
10.1084/jem.170.1.291
10.4049/jimmunol.139.5.1550 / J. Immunol / Direct activation of human resting T cells by IL–2: the role of an IL–2 receptor distinct from the TAG protein by Bich‐Thuy L. T. (1987)
10.1007/BF01665023
10.4049/jimmunol.142.2.490 / J. Immunol / IL–2 receptors on circulating natural killer cells and T lymphocytes. Similarity in number and affinity but difference in transmission of the proliferation signal by Aribia B. (1989)
10.1007/BF02171009
10.4049/jimmunol.139.2.443 / J. Immunol / rIL–2–induced proliferation of human circulating NK cells and T lymphocytes: synergistic effects of IL–1 and IL–2 by Aribia M‐H. B. (1987)
10.1111/j.1348-0421.1985.tb02960.x
10.4049/jimmunol.143.11.3548 / Immunol / Differential expression of the IL–2 receptor subunits, p55 and p75 on various populations of primary peripheral blood mononuclear cells. J by Ohashi Y. (1989)
10.1016/0198-8859(87)90110-8

Dates

Type	When
Created	20 years ago (Aug. 26, 2005, 4:27 p.m.)
Deposited	1 year, 7 months ago (Jan. 29, 2024, 3:44 a.m.)
Indexed	1 year, 7 months ago (Jan. 29, 2024, 4:38 a.m.)
Issued	34 years, 6 months ago (March 1, 1991)
Published	34 years, 6 months ago (March 1, 1991)
Published Online	20 years ago (Aug. 26, 2005)
Published Print	34 years, 6 months ago (March 1, 1991)

Funders 0

None

BibTeX

@article{Nakamura_1991, title={Macrophage–T Cell Interaction Is Essential for the Induction of p75 Interleukin 2 (IL–2) Receptor and IL–2 Responsiveness in Human CD4+T Cells}, volume={82}, ISSN={0910-5050}, url={http://dx.doi.org/10.1111/j.1349-7006.1991.tb01839.x}, DOI={10.1111/j.1349-7006.1991.tb01839.x}, number={3}, journal={Japanese Journal of Cancer Research}, publisher={Wiley}, author={Nakamura, Yoshihiko and Nishimura, Takashi and Tokuda, Yutaka and Kobayashi, Nobumasa and Watanabe, Katsuto and Noto, Takashi and Mitomi, Toshio and Sugamura, Kazuo and Habu, Sonoko}, year={1991}, month=mar, pages={257–261} }

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