DOI: 10.1111/j.1348-0421.2004.tb03500.x. Toll‐Like Receptor 3: A Link between Toll‐Like Receptor, Interferon and Viruses

Toll‐Like Receptor 3: A Link between Toll‐Like Receptor, Interferon and Viruses

10.1111/j.1348-0421.2004.tb03500.x

Crossref journal-article

Wiley

Microbiology and Immunology (311)

Abstract

AbstractProduction of type I interferon (IFN‐α/β) by virus‐infected cells is the central event in their antiviral immune responses. In mammalian cells, IFN‐α/β gene transcription is induced through distinct signaling pathways by viral infection or by treatment with double‐stranded (ds) RNA, which is an intermediate of virus replication. Toll‐like receptor 3 (TLR3) was found to recognize dsRNA and transmit signals to activate NF‐κB and the IFN‐β promoter. Recent identification of the TLR3‐adaptor protein and its downstream signaling molecules, which are involved in IFN‐α/β production, revealed a novel IFN‐inducing pathway for an anti‐viral immune response. Here, we summarize the current knowledge of TLR3‐mediated immune responses.

Bibliography

Matsumoto, M., Funami, K., Oshiumi, H., & Seya, T. (2004). TollâLike Receptor 3: A Link between TollâLike Receptor, Interferon and Viruses. Microbiology and Immunology, 48(3), 147â154. Portico.

Authors 4

Misako Matsumoto (first)
Kenji Funami (additional)
Hiroyuki Oshiumi (additional)
Tsukasa Seya (additional)

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Dates

Type	When
Created	11 years, 9 months ago (Nov. 14, 2013, 10:11 a.m.)
Deposited	1 year, 9 months ago (Nov. 20, 2023, 6:17 p.m.)
Indexed	3 months ago (May 27, 2025, 5:06 a.m.)
Issued	21 years, 5 months ago (March 1, 2004)
Published	21 years, 5 months ago (March 1, 2004)
Published Online	11 years, 9 months ago (Nov. 14, 2013)
Published Print	21 years, 5 months ago (March 1, 2004)

Funders 0

None

BibTeX

@article{Matsumoto_2004, title={Toll‐Like Receptor 3: A Link between Toll‐Like Receptor, Interferon and Viruses}, volume={48}, ISSN={1348-0421}, url={http://dx.doi.org/10.1111/j.1348-0421.2004.tb03500.x}, DOI={10.1111/j.1348-0421.2004.tb03500.x}, number={3}, journal={Microbiology and Immunology}, publisher={Wiley}, author={Matsumoto, Misako and Funami, Kenji and Oshiumi, Hiroyuki and Seya, Tsukasa}, year={2004}, month=mar, pages={147–154} }

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