DOI: 10.1111/j.1346-8138.1994.tb01809.x. The Effects of Sunscreens on UVB Erythema and Langerhans Cell Depression

The Effects of Sunscreens on UVB Erythema and Langerhans Cell Depression

10.1111/j.1346-8138.1994.tb01809.x

Crossref journal-article

Wiley

The Journal of Dermatology (311)

Abstract

AbstractLangerhans cells (LCs) are epidermal antigen‐presenting cells capable of initiating a specific T lymphocyte‐mediated immune response. It is a well known fact that ultraviolet light B (UVB) suppresses LC number and function.In this study, we confirmed that the sunscreens CITY BLOCK, and TOTAL SUN SHIELD 28 (Clinique Laboratories Tokyo, Japan) protected the epidermis against the depletion of LC number. We also investigated whether or not sunscreens could provide LC protection from ultraviolet ray (UVR) damage other than the prevention of the decrease in the total number of cells.Our data showed that the LC population was depressed after irradiation by 100 mJ/cm2 or 10 mJ/cm2 of UVB, but recovered to within normal levels after 16 days. Both sunscreens provided protection against erythema and LC depression due to UVB irradiation. However, despite the fact that these sunscreens had completely suppressed UVB erythema, shrinkage of LC dendrites was seen. Apparently, sunscreens prevent UVB erythema, but do not protect against functional changes in LC due to UVB.Recently, it has been reported that sunscreens are less effective in protecting against systemic immunosuppression that against inflammation. The shrinkage of LC dendrites despite sunscreen application may help explain this discrepancy.

Bibliography

Miyagi, T., Bhutto, A. M., & Nonaka, S. (1994). The Effects of Sunscreens on UVB Erythema and Langerhans Cell Depression. The Journal of Dermatology, 21(9), 645â651. Portico.

Authors 3

Tsuguna Miyagi (first)
Abdul Manan Bhutto (additional)
Shigeo Nonaka (additional)

References 14 Referenced 21

10.1111/1523-1747.ep12525745
10.1111/j.1751-1097.1989.tb05557.x
10.4049/jimmunol.124.1.445
10.1111/1523-1747.ep12506359
10.1016/S0190-9622(80)80221-0
10.1111/1523-1747.ep12610349
10.1111/1523-1747.ep12499926
10.1093/ajcp/27.1.13
10.1111/1523-1747.ep12470379
10.4049/jimmunol.136.10.3649 / J Immunol / Effect of gamma radiation on resting B lymphocytes I. Oxygen‐dependent damage to the plasma membrane results in increased permeability and cell enlargement by Ashwell JD (1986)
10.4049/jimmunol.141.8.2536 / J Immunol / Effect of gamma radiation on resting B lymphocytes II. Functional characterization of the antigen‐presentation defect by Ashwell JD (1988)
10.1111/1523-1747.ep12277156
10.1111/1523-1747.ep12483006
10.1111/1523-1747.ep12469038

Dates

Type	When
Created	10 years, 4 months ago (April 10, 2015, 3:21 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 6:34 a.m.)
Indexed	1 year, 10 months ago (Oct. 29, 2023, 7:58 a.m.)
Issued	31 years ago (Sept. 1, 1994)
Published	31 years ago (Sept. 1, 1994)
Published Online	10 years, 4 months ago (April 9, 2015)
Published Print	31 years ago (Sept. 1, 1994)

Funders 0

None

BibTeX

@article{Miyagi_1994, title={The Effects of Sunscreens on UVB Erythema and Langerhans Cell Depression}, volume={21}, ISSN={1346-8138}, url={http://dx.doi.org/10.1111/j.1346-8138.1994.tb01809.x}, DOI={10.1111/j.1346-8138.1994.tb01809.x}, number={9}, journal={The Journal of Dermatology}, publisher={Wiley}, author={Miyagi, Tsuguna and Bhutto, Abdul Manan and Nonaka, Shigeo}, year={1994}, month=sep, pages={645–651} }

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