DOI: 10.1110/ps.8.9.1752. Predicting conformational switches in proteins

Predicting conformational switches in proteins

10.1110/ps.8.9.1752

Crossref journal-article

Wiley

Protein Science (311)

Abstract

AbstractWe describe a new computational technique to predict conformationally switching elements in proteins from their amino acid sequences. The method, called ASP (Ambivalent Structure Predictor), analyzes results from a secondary structure prediction algorithm to identify regions of conformational ambivalence. ASP identifies ambivalent regions in 16 test protein sequences for which function involves substantial backbone rearrangements. In the test set, all sites previously described as conformational switches are correctly predicted to be structurally ambivalent regions. No such regions are predicted in three negative control protein sequences. ASP may be useful as a guide for experimental studies on protein function and motion in the absence of detailed three‐dimensional structural data.

Bibliography

Young, M., Kirshenbaum, K., Dill, K. A., & Highsmith, S. (1999). Predicting conformational switches in proteins. Protein Science, 8(9), 1752â1764. Portico.

Authors 4

Malin Young (first)
Kent Kirshenbaum (additional)
Ken A. Dill (additional)
Stefan Highsmith (additional)

References 53 Referenced 60

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{'key': 'e_1_2_1_36_1', 'first-page': '535', 'article-title': 'PHD: Predicting one‐dimensional protein structure by profile‐based neural networks', 'volume': '266', 'author': 'Rost B', 'year': '1996', 'journal-title': 'Methods Enzymol'} / Methods Enzymol / PHD: Predicting one‐dimensional protein structure by profile‐based neural networks by Rost B (1996)
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Dates

Type	When
Created	16 years, 6 months ago (Feb. 17, 2009, 2:57 p.m.)
Deposited	1 year, 10 months ago (Oct. 28, 2023, 3:21 p.m.)
Indexed	1 year ago (Aug. 14, 2024, 6:32 a.m.)
Issued	26 years, 8 months ago (Jan. 1, 1999)
Published	26 years, 8 months ago (Jan. 1, 1999)
Published Online	16 years, 8 months ago (Dec. 31, 2008)
Published Print	26 years, 8 months ago (Jan. 1, 1999)

Funders 0

None

BibTeX

@article{Young_1999, title={Predicting conformational switches in proteins}, volume={8}, ISSN={1469-896X}, url={http://dx.doi.org/10.1110/ps.8.9.1752}, DOI={10.1110/ps.8.9.1752}, number={9}, journal={Protein Science}, publisher={Wiley}, author={Young, Malin and Kirshenbaum, Kent and Dill, Ken A. and Highsmith, Stefan}, year={1999}, month=jan, pages={1752–1764} }

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