DOI: 10.1110/ps.041024904. FTIR reveals structural differences between native β‐sheet proteins and amyloid fibrils

FTIR reveals structural differences between native β‐sheet proteins and amyloid fibrils

10.1110/ps.041024904

Crossref journal-article

Wiley

Protein Science (311)

Abstract

AbstractThe presence of β‐sheets in the core of amyloid fibrils raised questions as to whether or not β‐sheet‐containing proteins, such as transthyretin, are predisposed to form such fibrils. However, we show here that the molecular structure of amyloid fibrils differs more generally from the β‐sheets in native proteins. This difference is evident from the amide I region of the infrared spectrum and relates to the distribution of the ϕ/ψ dihedral angles within the Ramachandran plot, the average number of strands per sheet, and possibly, the β‐sheet twist. These data imply that amyloid fibril formation from native β‐sheet proteins can involve a substantial structural reorganization.

Bibliography

Zandomeneghi, G., Krebs, M. R. H., McCammon, M. G., & FÃ¤ndrich, M. (2004). FTIR reveals structural differences between native Î²âsheet proteins and amyloid fibrils. Protein Science, 13(12), 3314â3321. Portico.

Authors 4

Giorgia Zandomeneghi (first)
Mark R.H. Krebs (additional)
Margaret G. McCammon (additional)
Marcus Fändrich (additional)

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Dates

Type	When
Created	20 years, 9 months ago (Nov. 10, 2004, 8:26 p.m.)
Deposited	1 year, 10 months ago (Oct. 12, 2023, 4:15 p.m.)
Indexed	7 hours, 30 minutes ago (Aug. 24, 2025, 7:07 p.m.)
Issued	20 years, 8 months ago (Dec. 1, 2004)
Published	20 years, 8 months ago (Dec. 1, 2004)
Published Online	16 years, 7 months ago (Jan. 1, 2009)
Published Print	20 years, 8 months ago (Dec. 1, 2004)

Funders 0

None

BibTeX

@article{Zandomeneghi_2004, title={FTIR reveals structural differences between native β‐sheet proteins and amyloid fibrils}, volume={13}, ISSN={1469-896X}, url={http://dx.doi.org/10.1110/ps.041024904}, DOI={10.1110/ps.041024904}, number={12}, journal={Protein Science}, publisher={Wiley}, author={Zandomeneghi, Giorgia and Krebs, Mark R.H. and McCammon, Margaret G. and Fändrich, Marcus}, year={2004}, month=dec, pages={3314–3321} }

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