DOI: 10.1107/s0907444902016608. The prospects of protein nanocrystallography

The prospects of protein nanocrystallography

10.1107/s0907444902016608

Crossref journal-article

International Union of Crystallography (IUCr)

Acta Crystallographica Section D Biological Crystallography (329)

Abstract

The miniaturization of protein crystallography's experimental method has several advantages. Firstly, it reduces the amount of protein required for identifying crystallization conditions, allowing crystallographic studies of rare natural proteins and complexes. Secondly, higher levels of supersaturation can be obtained in very small volumes, allowing the exploration of additional crystallization conditions. Thirdly, there are indications that protein crystals grown in very small volumes may be better ordered. Fourthly, miniaturization and automation go hand in hand, opening the prospects of easier and more reproducible experimentation. Progress in the development of nanocrystallography is discussed and the remaining bottlenecks are highlighted.

Bibliography

Bodenstaff, E. R., Hoedemaeker, F. J., Kuil, M. E., de Vrind, H. P. M., & Abrahams, J. P. (2002). The prospects of protein nanocrystallography. Acta Crystallographica Section D Biological Crystallography, 58(11), 1901â1906.

Authors 5

E. Rene Bodenstaff (first)
Flip J. Hoedemaeker (additional)
Maxim E. Kuil (additional)
Hans P. M. de Vrind (additional)
Jan Pieter Abrahams (additional)

References 0 Referenced 36

None

Dates

Type	When
Created	22 years, 10 months ago (Oct. 23, 2002, 5:33 a.m.)
Deposited	7 months, 2 weeks ago (Jan. 11, 2025, 9:06 a.m.)
Indexed	7 months, 2 weeks ago (Jan. 11, 2025, 9:40 a.m.)
Issued	22 years, 10 months ago (Oct. 21, 2002)
Published	22 years, 10 months ago (Oct. 21, 2002)
Published Online	22 years, 10 months ago (Oct. 21, 2002)
Published Print	22 years, 9 months ago (Nov. 1, 2002)

Funders 0

None

BibTeX

@article{Bodenstaff_2002, title={The prospects of protein nanocrystallography}, volume={58}, ISSN={0907-4449}, url={http://dx.doi.org/10.1107/s0907444902016608}, DOI={10.1107/s0907444902016608}, number={11}, journal={Acta Crystallographica Section D Biological Crystallography}, publisher={International Union of Crystallography (IUCr)}, author={Bodenstaff, E. Rene and Hoedemaeker, Flip J. and Kuil, Maxim E. and de Vrind, Hans P. M. and Abrahams, Jan Pieter}, year={2002}, month=oct, pages={1901–1906} }

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