DOI: 10.1101/lm.5.6.467. On the Respective Roles of Nitric Oxide and Carbon Monoxide in Long-Term Potentiation in the Hippocampus

On the Respective Roles of Nitric Oxide and Carbon Monoxide in Long-Term Potentiation in the Hippocampus

10.1101/lm.5.6.467

Crossref journal-article

Cold Spring Harbor Laboratory

Learning & Memory (246)

Abstract

Perfusion of hippocampal slices with an inhibitor of nitric oxide (NO) synthase-blocked induction of long-term potentiation (LTP) produced by a one-train tetanus and significantly reduced LTP by a two-train tetanus, but only slightly reduced LTP by a four-train tetanus. Inhibitors of heme oxygenase, the synthetic enzyme for carbon monoxide (CO), significantly reduced LTP by either a two-train or four-train tetanus. These results suggest that NO and CO are both involved in LTP but may play somewhat different roles. One possibility is that NO serves a phasic, signaling role, whereas CO provides tonic, background stimulation. Another possibility is that NO and CO are phasically activated under somewhat different circumstances, perhaps involving different receptors and second messengers. Because NO is known to be activated by stimulation of NMDA receptors during tetanus, we investigated the possibility that CO might be activated by stimulation of metabotropic glutamate receptors (mGluRs). Consistent with this idea, long-lasting potentiation by the mGluR agonist tACPD was blocked by inhibitors of heme oxygenase but not NO synthase. Potentiation by tACPD was also blocked by inhibitors of soluble guanylyl cyclase (a target of both NO and CO) or cGMP-dependent protein kinase, and guanylyl cyclase was activated by tACPD in hippocampal slices. However, biochemical assays indicate that whereas heme oxygenase is constitutively active in hippocampus, it does not appear to be stimulated by either tetanus or tACPD. These results are most consistent with the possibility that constitutive (tonic) rather than stimulated (phasic) heme oxygenase activity is necessary for potentiation by tetanus or tACPD, and suggest that mGluR activation stimulates guanylyl cyclase phasically through some other pathway.

Bibliography

Zhuo, M., Laitinen, J. T., Li, X.-C., & Hawkins, R. D. (1998). On the Respective Roles of Nitric Oxide and Carbon Monoxide in Long-Term Potentiation in the Hippocampus. Learning & Memory, 5(6), 467â480.

Authors 4

Min Zhuo (first)
Jarmo T. Laitinen (additional)
Xiao-Ching Li (additional)
Robert D. Hawkins (additional)

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Dates

Type	When
Created	3 years, 9 months ago (Nov. 11, 2021, 8:53 a.m.)
Deposited	3 years, 9 months ago (Nov. 11, 2021, 8:54 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 11, 2024, 12:42 a.m.)
Issued	26 years, 10 months ago (Nov. 1, 1998)
Published	26 years, 10 months ago (Nov. 1, 1998)
Published Online	26 years, 10 months ago (Nov. 1, 1998)
Published Print	26 years, 10 months ago (Nov. 1, 1998)

Funders 0

None

BibTeX

@article{Zhuo_1998, title={On the Respective Roles of Nitric Oxide and Carbon Monoxide in Long-Term Potentiation in the Hippocampus}, volume={5}, ISSN={1549-5485}, url={http://dx.doi.org/10.1101/lm.5.6.467}, DOI={10.1101/lm.5.6.467}, number={6}, journal={Learning & Memory}, publisher={Cold Spring Harbor Laboratory}, author={Zhuo, Min and Laitinen, Jarmo T. and Li, Xiao-Ching and Hawkins, Robert D.}, year={1998}, month=nov, pages={467–480} }

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