DOI: 10.1101/gr.9.11.1106. Exploring Expression Data: Identification and Analysis of Coexpressed Genes

Exploring Expression Data: Identification and Analysis of Coexpressed Genes

10.1101/gr.9.11.1106

Crossref journal-article

Cold Spring Harbor Laboratory

Genome Research (246)

Abstract

Analysis procedures are needed to extract useful information from the large amount of gene expression data that is becoming available. This work describes a set of analytical tools and their application to yeast cell cycle data. The components of our approach are (1) a similarity measure that reduces the number of false positives, (2) a new clustering algorithm designed specifically for grouping gene expression patterns, and (3) an interactive graphical cluster analysis tool that allows user feedback and validation. We use the clusters generated by our algorithm to summarize genome-wide expression and to initiate supervised clustering of genes into biologically meaningful groups.

Bibliography

Heyer, L. J., Kruglyak, S., & Yooseph, S. (1999). Exploring Expression Data: Identification and Analysis of Coexpressed Genes. Genome Research, 9(11), 1106â1115.

Authors 3

Laurie J. Heyer (first)
Semyon Kruglyak (additional)
Shibu Yooseph (additional)

References 20 Referenced 751

10.1073/pnas.96.12.6745
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Hartigan J. (1975) Clustering algorithms. (John Wiley & Sons, New York, NY).
Kaufman L. Rousseeuw P. (1990) Finding groups in data: An introduction to cluster analysis. (John Wiley & Sons, New York, NY). (10.1002/9780470316801)
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 8 p.m.)
Deposited	3 years, 9 months ago (Nov. 18, 2021, 1:47 p.m.)
Indexed	13 hours, 59 minutes ago (Sept. 6, 2025, 3:54 p.m.)
Issued	25 years, 10 months ago (Nov. 1, 1999)
Published	25 years, 10 months ago (Nov. 1, 1999)
Published Online	25 years, 10 months ago (Nov. 1, 1999)
Published Print	25 years, 10 months ago (Nov. 1, 1999)

Funders 0

None

BibTeX

@article{Heyer_1999, title={Exploring Expression Data: Identification and Analysis of Coexpressed Genes}, volume={9}, ISSN={1549-5469}, url={http://dx.doi.org/10.1101/gr.9.11.1106}, DOI={10.1101/gr.9.11.1106}, number={11}, journal={Genome Research}, publisher={Cold Spring Harbor Laboratory}, author={Heyer, Laurie J. and Kruglyak, Semyon and Yooseph, Shibu}, year={1999}, month=nov, pages={1106–1115} }

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