DOI: 10.1101/gr.212701. Evolution of Gene Order in the Genomes of Two Related Yeast Species

Evolution of Gene Order in the Genomes of Two Related Yeast Species

10.1101/gr.212701

Crossref journal-article

Cold Spring Harbor Laboratory

Genome Research (246)

Abstract

Changes in gene order between the genomes of two related yeast species, Saccharomyces cerevisiae and Saccharomyces bayanus var. uvarum were studied. From the dataset of a previous low coverage sequencing of the S. bayanus var.uvarum genome, 35 different synteny breakpoints between neighboring genes and two cases of local gene inversion were characterized in detail. The number and the type of the chromosomal rearrangements that have lead to these differences were identified. We show that evolution of gene order in the genomes of these two yeast species is driven mainly by gene duplication onto different chromosomes followed by differential loss of the repeated copies. In addition, local gene inversions also would result from a mechanism of gene duplication, but in an inverted orientation, followed by loss of the original copy. The identification of traces of anciently duplicated genes, called relics, show that the loss of duplicates is more frequently caused by the accumulation of numerous mutations in one of the two copies than by DNA deletion. Surprisingly, gross chromosomal rearrangements such as translocations have only a minor effect on gene order reshuffling as they account for <10% of the synteny breakpoints.[The sequence data have been submitted to the EMBL Library under accession nos. AJ316068 and AJ316069.]

Bibliography

Fischer, G., NeuvÃ©glise, C., Durrens, P., Gaillardin, C., & Dujon, B. (2001). Evolution of Gene Order in the Genomes of Two Related Yeast Species. Genome Research, 11(12), 2009â2019.

Authors 5

Gilles Fischer (first)
Cécile Neuvéglise (additional)
Pascal Durrens (additional)
Claude Gaillardin (additional)
Bernard Dujon (additional)

References 30 Referenced 75

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{'key': '2021111810462063000_11.12.2009.14', 'first-page': '367', 'article-title': 'Two yeast chromosomes are related by a fossil duplication of their centromeric regions.', 'volume': '316', 'author': 'Lalo', 'year': '1993', 'journal-title': 'C. R. Acad. Sci. III'} / C. R. Acad. Sci. III / Two yeast chromosomes are related by a fossil duplication of their centromeric regions. by Lalo (1993)
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10.1038/42711

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 7:59 p.m.)
Deposited	3 years, 9 months ago (Nov. 18, 2021, 2:06 p.m.)
Indexed	6 days, 15 hours ago (Aug. 27, 2025, 12:32 p.m.)
Issued	23 years, 9 months ago (Dec. 1, 2001)
Published	23 years, 9 months ago (Dec. 1, 2001)
Published Online	23 years, 9 months ago (Dec. 1, 2001)
Published Print	23 years, 9 months ago (Dec. 1, 2001)

Funders 0

None

BibTeX

@article{Fischer_2001, title={Evolution of Gene Order in the Genomes of Two Related Yeast Species}, volume={11}, ISSN={1549-5469}, url={http://dx.doi.org/10.1101/gr.212701}, DOI={10.1101/gr.212701}, number={12}, journal={Genome Research}, publisher={Cold Spring Harbor Laboratory}, author={Fischer, Gilles and Neuvéglise, Cécile and Durrens, Pascal and Gaillardin, Claude and Dujon, Bernard}, year={2001}, month=dec, pages={2009–2019} }

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