DOI: 10.1101/gr.1680803. Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans

Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans

10.1101/gr.1680803

Crossref journal-article

Cold Spring Harbor Laboratory

Genome Research (246)

Abstract

Human Protein Reference Database (HPRD) is an object database that integrates a wealth of information relevant to the function of human proteins in health and disease. Data pertaining to thousands of protein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease associations, tissue expression, and subcellular localization were extracted from the literature for a nonredundant set of 2750 human proteins. Almost all the information was obtained manually by biologists who read and interpreted >300,000 published articles during the annotation process. This database, which has an intuitive query interface allowing easy access to all the features of proteins, was built by using open source technologies and will be freely available at http://www.hprd.org to the academic community. This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era.

Bibliography

Peri, S., Navarro, J. D., Amanchy, R., Kristiansen, T. Z., Jonnalagadda, C. K., Surendranath, V., Niranjan, V., Muthusamy, B., Gandhi, T. K. B., Gronborg, M., Ibarrola, N., Deshpande, N., Shanker, K., Shivashankar, H. N., Rashmi, B. P., Ramya, M. A., Zhao, Z., Chandrika, K. N., Padma, N., â¦ Pandey, A. (2003). Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans. Genome Research, 13(10), 2363â2371.

Authors 52

Suraj Peri (first)
J. Daniel Navarro (additional)
Ramars Amanchy (additional)
Troels Z. Kristiansen (additional)
Chandra Kiran Jonnalagadda (additional)
Vineeth Surendranath (additional)
Vidya Niranjan (additional)
Babylakshmi Muthusamy (additional)
T.K.B. Gandhi (additional)
Mads Gronborg (additional)
Nieves Ibarrola (additional)
Nandan Deshpande (additional)
K. Shanker (additional)
H.N. Shivashankar (additional)
B.P. Rashmi (additional)
M.A. Ramya (additional)
Zhixing Zhao (additional)
K.N. Chandrika (additional)
N. Padma (additional)
H.C. Harsha (additional)
A.J. Yatish (additional)
M.P. Kavitha (additional)
Minal Menezes (additional)
Dipanwita Roy Choudhury (additional)
Shubha Suresh (additional)
Neelanjana Ghosh (additional)
R. Saravana (additional)
Sreenath Chandran (additional)
Subhalakshmi Krishna (additional)
Mary Joy (additional)
Sanjeev K. Anand (additional)
V. Madavan (additional)
Ansamma Joseph (additional)
Guang W. Wong (additional)
William P. Schiemann (additional)
Stefan N. Constantinescu (additional)
Lily Huang (additional)
Roya Khosravi-Far (additional)
Hanno Steen (additional)
Muneesh Tewari (additional)
Saghi Ghaffari (additional)
Gerard C. Blobe (additional)
Chi V. Dang (additional)
Joe G.N. Garcia (additional)
Jonathan Pevsner (additional)
Ole N. Jensen (additional)
Peter Roepstorff (additional)
Krishna S. Deshpande (additional)
Arul M. Chinnaiyan (additional)
Ada Hamosh (additional)
Aravinda Chakravarti (additional)
Akhilesh Pandey (additional)

References 41 Referenced 874

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http://www.hprd.org; Human Protein Reference Database.
http://www.ibioinformatics.org; Institute of Bioinformatics home page.

Dates

Type	When
Created	21 years, 11 months ago (Oct. 2, 2003, 5:38 p.m.)
Deposited	3 years, 9 months ago (Nov. 18, 2021, 2:23 p.m.)
Indexed	59 minutes ago (Sept. 3, 2025, 6 a.m.)
Issued	21 years, 11 months ago (Oct. 1, 2003)
Published	21 years, 11 months ago (Oct. 1, 2003)
Published Online	21 years, 11 months ago (Oct. 2, 2003)
Published Print	21 years, 11 months ago (Oct. 1, 2003)

Funders 0

None

BibTeX

@article{Peri_2003, title={Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans}, volume={13}, ISSN={1088-9051}, url={http://dx.doi.org/10.1101/gr.1680803}, DOI={10.1101/gr.1680803}, number={10}, journal={Genome Research}, publisher={Cold Spring Harbor Laboratory}, author={Peri, Suraj and Navarro, J. Daniel and Amanchy, Ramars and Kristiansen, Troels Z. and Jonnalagadda, Chandra Kiran and Surendranath, Vineeth and Niranjan, Vidya and Muthusamy, Babylakshmi and Gandhi, T.K.B. and Gronborg, Mads and Ibarrola, Nieves and Deshpande, Nandan and Shanker, K. and Shivashankar, H.N. and Rashmi, B.P. and Ramya, M.A. and Zhao, Zhixing and Chandrika, K.N. and Padma, N. and Harsha, H.C. and Yatish, A.J. and Kavitha, M.P. and Menezes, Minal and Choudhury, Dipanwita Roy and Suresh, Shubha and Ghosh, Neelanjana and Saravana, R. and Chandran, Sreenath and Krishna, Subhalakshmi and Joy, Mary and Anand, Sanjeev K. and Madavan, V. and Joseph, Ansamma and Wong, Guang W. and Schiemann, William P. and Constantinescu, Stefan N. and Huang, Lily and Khosravi-Far, Roya and Steen, Hanno and Tewari, Muneesh and Ghaffari, Saghi and Blobe, Gerard C. and Dang, Chi V. and Garcia, Joe G.N. and Pevsner, Jonathan and Jensen, Ole N. and Roepstorff, Peter and Deshpande, Krishna S. and Chinnaiyan, Arul M. and Hamosh, Ada and Chakravarti, Aravinda and Pandey, Akhilesh}, year={2003}, month=oct, pages={2363–2371} }

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