DOI: 10.1101/gr.147400. HEAT Repeats Associated with Condensins, Cohesins, and Other Complexes Involved in Chromosome-Related Functions

HEAT Repeats Associated with Condensins, Cohesins, and Other Complexes Involved in Chromosome-Related Functions

10.1101/gr.147400

Crossref journal-article

Cold Spring Harbor Laboratory

Genome Research (246)

Abstract

HEAT repeats correspond to tandemly arranged curlicue-like structures that appear to serve as flexible scaffolding on which other components can assemble. Using sensitive sequence analysis techniques we detected HEAT repeats in various chromosome-associated proteins, including four families of proteins associated with condensins and cohesins, which are nuclear complexes that contain structural maintenance of chromosome (SMC) proteins. Among the proteins detected were the XCAP-D2 and XCAP-G subunits of the Xenopus laevis 13S condensin complex, the Aspergillus BimD and Sordaria macrospora Spo76p proteins, the budding yeast Scc2p protein, and the related Drosophila transcriptional activator Nipped-B. Clathrin adaptor and COP-I coatomer subunits, which function in vesicle coat assembly and were previously noted to share weak sequence similarity to condensin subunits, also contain HEAT repeats. HEAT repeats were also found in the TBP-associated TIP120 protein, a global enhancer of transcription, and in the budding yeast Mot1p protein, which is a member of the SWI2/SNF2 family. SWI2/SNF2 proteins, some of which are helicases, perform diverse roles in transcription control, DNA repair, and chromosome segregation and form chromatin-remodeling complexes. HEAT repeats also were found in dis1-TOG family and cofactor D family microtubule-associated proteins, which, owing to their roles in microtubule dynamics, perform functions related to mitotic progression and chromosome segregation. Hence, our analysis predicts structural features of these proteins and suggests that HEAT repeats may play important roles in chromosome dynamics.

Bibliography

Neuwald, A. F., & Hirano, T. (2000). HEAT Repeats Associated with Condensins, Cohesins, and Other Complexes Involved in Chromosome-Related Functions. Genome Research, 10(10), 1445â1452.

Authors 2

Andrew F. Neuwald (first)
Tatsuya Hirano (additional)

References 53 Referenced 236

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{'key': '2021111810350408000_10.10.1445.10', 'first-page': '1879', 'article-title': 'A presumptive helicase (MOT1 gene product) affects gene expression and is required for viability in the yeast Saccharomyces cerevisiae.', 'volume': '12', 'author': 'Davis', 'year': '1992', 'journal-title': 'Mol. Cell Biol.'} / Mol. Cell Biol. / A presumptive helicase (MOT1 gene product) affects gene expression and is required for viability in the yeast Saccharomyces cerevisiae. by Davis (1992)
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Dates

Type	When
Created	23 years ago (July 26, 2002, 8 p.m.)
Deposited	3 years, 9 months ago (Nov. 18, 2021, 1:51 p.m.)
Indexed	2 weeks, 4 days ago (Aug. 7, 2025, 5:13 p.m.)
Issued	24 years, 10 months ago (Oct. 1, 2000)
Published	24 years, 10 months ago (Oct. 1, 2000)
Published Online	24 years, 10 months ago (Oct. 1, 2000)
Published Print	24 years, 10 months ago (Oct. 1, 2000)

Funders 0

None

BibTeX

@article{Neuwald_2000, title={HEAT Repeats Associated with Condensins, Cohesins, and Other Complexes Involved in Chromosome-Related Functions}, volume={10}, ISSN={1549-5469}, url={http://dx.doi.org/10.1101/gr.147400}, DOI={10.1101/gr.147400}, number={10}, journal={Genome Research}, publisher={Cold Spring Harbor Laboratory}, author={Neuwald, Andrew F. and Hirano, Tatsuya}, year={2000}, month=oct, pages={1445–1452} }

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      [
        2000,
        10,
        1
      ]
    ]
  }
}