DOI: 10.1101/gr.142200. Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

10.1101/gr.142200

Crossref journal-article

Cold Spring Harbor Laboratory

Genome Research (246)

Abstract

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF276990.]

Bibliography

Dubchak, I., Brudno, M., Loots, G. G., Pachter, L., Mayor, C., Rubin, E. M., & Frazer, K. A. (2000). Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons. Genome Research, 10(9), 1304â1306.

Authors 7

Inna Dubchak (first)
Michael Brudno (additional)
Gabriela G. Loots (additional)
Lior Pachter (additional)
Chris Mayor (additional)
Edward M. Rubin (additional)
Kelly A. Frazer (additional)

References 8 Referenced 238

{'key': '2021111810345859000_10.9.1304.1', 'first-page': '29', 'article-title': 'Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.', 'volume': '8', 'author': 'Ansari-Lari', 'year': '1998', 'journal-title': 'Genome Res.'} / Genome Res. / Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. by Ansari-Lari (1998)
Batzoglou, S., Pachter, L., Mesirov, J.P., Berger, B., and Lander, E.S. 2000. Human and mouse gene structure: Comparative analysis and application to exon prediction. Genome Res. (in press).. (10.1145/332306.332326)
10.1038/72635
10.1101/gr.7.10.959
{'key': '2021111810345859000_10.9.1304.5', 'first-page': '3239', 'article-title': 'A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer.', 'volume': '149', 'author': 'Henkel', 'year': '1992', 'journal-title': 'Immunology'} / Immunology / A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer. by Henkel (1992)
10.1038/ng0594-48
10.1126/science.288.5463.136
10.1101/gr.7.4.315

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 8 p.m.)
Deposited	3 years, 9 months ago (Nov. 18, 2021, 1:54 p.m.)
Indexed	4 weeks ago (Aug. 7, 2025, 4:37 p.m.)
Issued	25 years ago (Sept. 1, 2000)
Published	25 years ago (Sept. 1, 2000)
Published Online	25 years ago (Sept. 1, 2000)
Published Print	25 years ago (Sept. 1, 2000)

Funders 0

None

BibTeX

@article{Dubchak_2000, title={Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons}, volume={10}, ISSN={1549-5469}, url={http://dx.doi.org/10.1101/gr.142200}, DOI={10.1101/gr.142200}, number={9}, journal={Genome Research}, publisher={Cold Spring Harbor Laboratory}, author={Dubchak, Inna and Brudno, Michael and Loots, Gabriela G. and Pachter, Lior and Mayor, Chris and Rubin, Edward M. and Frazer, Kelly A.}, year={2000}, month=sep, pages={1304–1306} }

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