DOI: 10.1101/gr.138802. Tandem Repeats in Protein Coding Regions of Primate Genes

Tandem Repeats in Protein Coding Regions of Primate Genes

10.1101/gr.138802

Crossref journal-article

Cold Spring Harbor Laboratory

Genome Research (246)

Abstract

Tandem repeats in GenBank primate nucleotide sequences annotated as protein coding regions are analyzed. It is found that only trinucleotide repeats show repeat enrichment well above the threshold of statistical significance. The statistics are improved by a simultaneous search for repeats on both the amino acid and nucleotide levels. The results of the analyses of natural sequences are interpreted by comparing them with the results of the computer simulation of the model dedicated to protein coding regions. According to the simulation results, a limited set of trinucleotides, that is, cgg, ccg, cag, and gaa repeats coding for polyalanine, polyglycine, polyproline, polyglutamine, and polylysine are prone to proliferation. It is also found that within the repeat regions slippage is more frequent by a factor of 10 than point mutations, whereas the ratio of silent versus recognizable point mutations is approximately the same as elsewhere in coding regions. The trinucleotide repeats cover slightly more than 0.3% of the protein coding regions of genes.

Bibliography

BorÅ¡tnik, B., & Pumpernik, D. (2002). Tandem Repeats in Protein Coding Regions of Primate Genes. Genome Research, 12(6), 909â915.

Authors 2

Branko Borštnik (first)
Danilo Pumpernik (additional)

References 13 Referenced 60

10.1016/S0097-8485(96)80006-4
10.1093/nar/28.1.15
10.1209/0295-5075/23/6/002 / Europhys. Lett. / Analysis of apparent 1/f spectrum in DNA sequences. by BorÅ¡tnik (1993)
10.1093/nar/22.16.3412
10.1073/pnas.94.10.5237
10.1002/1521-1878(200012)22:12<1153::AID-BIES13>3.0.CO;2-0
10.1073/pnas.95.4.1647
10.1038/35057062
10.1073/pnas.95.18.10774
{'key': '2021111810470130000_12.6.909.10', 'first-page': '72', 'article-title': 'Selection against frameshift mutations limits microsatellite expansion in coding DNA.', 'volume': '10', 'author': 'Metzgar', 'year': '2000', 'journal-title': 'Genome Res.'} / Genome Res. / Selection against frameshift mutations limits microsatellite expansion in coding DNA. by Metzgar (2000)
10.1093/nar/28.1.292
10.1006/jmbi.1999.3275
10.1101/gr.10.7.967

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 8 p.m.)
Deposited	3 years, 9 months ago (Nov. 18, 2021, 2:09 p.m.)
Indexed	1 year, 1 month ago (July 18, 2024, 9:14 a.m.)
Issued	23 years, 2 months ago (June 1, 2002)
Published	23 years, 2 months ago (June 1, 2002)
Published Online	23 years, 2 months ago (June 1, 2002)
Published Print	23 years, 2 months ago (June 1, 2002)

Funders 0

None

BibTeX

@article{Bor_tnik_2002, title={Tandem Repeats in Protein Coding Regions of Primate Genes}, volume={12}, ISSN={1549-5469}, url={http://dx.doi.org/10.1101/gr.138802}, DOI={10.1101/gr.138802}, number={6}, journal={Genome Research}, publisher={Cold Spring Harbor Laboratory}, author={Borštnik, Branko and Pumpernik, Danilo}, year={2002}, month=jun, pages={909–915} }

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