DOI: 10.1101/gad.962502. Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression

Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression

10.1101/gad.962502

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

Specific recruitment of corepressor complexes containing histone deacetylases (HDAC) by transcription factors is believed to play an essential role in transcriptional repression. Recent studies indicate that repression by unliganded nuclear hormone receptors and by the Mad family of repressors requires distinct HDAC-containing corepressor complexes. In this work, we show that unliganded TR specifically recruits only the closely related N-CoR and SMRT–HDAC3 complexes, whereas the Mad1 recruits only the Sin3–HDAC1/2 complex. Significantly, both the Sin3 and Mi-2/NURD complexes also exhibit constitutive association with chromatin and contribute to chromatin deacetylation in a nontargeted fashion. These results suggest that HDAC complexes can contribute to gene repression by two distinct mechanisms as follows: (1) specific targeting by repressors and (2) constitutive association with chromatin.

Bibliography

Li, J., Lin, Q., Wang, W., Wade, P., & Wong, J. (2002). Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression. Genes & Development, 16(6), 687â692.

Authors 5

Jiwen Li (first)
Qiushi Lin (additional)
Weidong Wang (additional)
Paul Wade (additional)
Jiemin Wong (additional)

References 29 Referenced 103

10.1038/387049a0
10.1101/gad.7.10.2033
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10.1101/gad.14.1.45 / Genes & Dev. / Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. by Huang (2000)
10.1101/gad.14.1.55 / Genes & Dev. / Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. by Kao (2000)
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10.1016/S0960-9822(98)70328-8
10.1038/12664 / Nat. Genet. / Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. by Wade (1999)
10.1073/pnas.97.13.7202
10.1046/j.1365-2443.1997.1260323.x
10.1101/gad.9.21.2696
10.1093/emboj/17.2.520
10.1016/S1097-2765(00)80299-3
10.1016/S0092-8674(00)80216-0
10.1016/S0092-8674(00)81758-4

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 7:59 p.m.)
Deposited	3 years, 9 months ago (Nov. 15, 2021, 11:03 a.m.)
Indexed	1 month ago (July 26, 2025, 5:24 a.m.)
Issued	23 years, 5 months ago (March 15, 2002)
Published	23 years, 5 months ago (March 15, 2002)
Published Online	23 years, 5 months ago (March 15, 2002)
Published Print	23 years, 5 months ago (March 15, 2002)

Funders 0

None

BibTeX

@article{Li_2002, title={Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression}, volume={16}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.962502}, DOI={10.1101/gad.962502}, number={6}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Li, Jiwen and Lin, Qiushi and Wang, Weidong and Wade, Paul and Wong, Jiemin}, year={2002}, month=mar, pages={687–692} }

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