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Cold Spring Harbor Laboratory
Genes & Development (246)
Bibliography

Ingham, P. W., & McMahon, A. P. (2001). Hedgehog signaling in animal development: paradigms and principles. Genes & Development, 15(23), 3059–3087.

Authors 2
  1. Philip W. Ingham (first)
  2. Andrew P. McMahon (additional)
References 318 Referenced 2,457
  1. 10.1126/science.1058624 / Science / Sonic hedgehog control of size and shape in midbrain pattern formation. by Agarwala (2001)
  2. 10.1016/S0960-9822(00)80052-4 / Curr. Biol. / Inhibition of sonic hedgehog signaling in vivo results in craniofacial neural crest cell death. by Ahlgren (1999)
  3. 10.1016/S0092-8674(00)80094-X / Cell / The Drosophila smoothened gene encodes a 7-pass membrane-protein, a putative receptor for the hedgehog signal. by Alcedo (1996)
  4. 10.1016/S1097-2765(00)00044-7 / Mol. Cell / Post-transcriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. by Alcedo (2000)
  5. 10.1101/gad.10.16.2003 / Genes & Dev. / Transcriptional activation of Hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. by Alexandre (1996)
  6. 10.1242/dev.126.24.5689 / Development / Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals. by Alexandre (1999)
  7. 10.1016/S0925-4773(98)00130-0 / Mech. Dev. / Modulation of Hedgehog target gene expression by the fused serine-threonine kinase in wing imaginal discs. by Alves (1998)
  8. 10.1101/gr.9.10.909 / Genome Res. / Caenorhabditis elegans has scores of hedgehog-related genes: Sequence and expression analysis. by Aspock (1999)
  9. 10.1016/S0092-8674(00)80292-5 / Cell / Proteolysis that is inhibited by hedgehog targets cubitus interruptus protein to the nucleus and converts it to a repressor. by Aza-Blanc (1997)
  10. 10.1242/dev.127.19.4293 / Development / Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. by Aza-Blanc (2000)
  11. 10.1038/368208a0 / Nature / Compartment boundaries and the control of Drosophila limb pattern by Hedgehog protein. by Basler (1994)
  12. 10.1038/27932 / Nature / tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. by Bellaiche (1998)
  13. 10.1038/ng1196-353 / Nat. Genet. / Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. by Belloni (1996)
  14. 10.1242/dev.124.1.53 / Development / Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. by Bellusci (1997)
  15. 10.1002/bies.1069 / BioEssays / Developmental roles of platelet-derived growth factors. by Betsholtz (2001)
  16. 10.1038/84282 / Nat. Immunol. / Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. by Bhardwaj (2001)
  17. 10.1002/gene.1057 / Genesis / Sonic hedgehog and Tiggy-winkle hedgehog cooperatively induce zebrafish branchiomotor neurons. by Bingham (2001)
  18. 10.1016/S0960-9822(02)00480-3 / Curr. Biol. / Sertoli-cell signaling by Desert hedgehog regulates the male germline. by Bitgood (1996)
  19. 10.1101/gad.11.17.2163 / Genes & Dev. / Notochord induction of zebrafish slow muscle is mediated by Sonic hedgehog. by Blagden (1997)
  20. 10.1016/S1388-1981(00)00055-X / Biochim. Biophys. Acta / Intracellular cholesterol trafficking: Role of the NPC1 protein. by Blanchette-Mackie (2000)
  21. Borycki A. (2001) Sonic hedgehog and Wnt signalling pathways during development and evolution. in Modularity in development and evolution, ed Schlosser G. (Chicago University Press, Chicago) (in press)..
  22. 10.1242/dev.126.18.4053 / Development / Sonic hedgehog controls epaxial muscle determination through myf5 activation. by Borycki (1999)
  23. 10.1016/S0092-8674(00)80853-3 / Cell / A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. by Briscoe (2000)
  24. 10.1016/S1097-2765(01)00271-4 / Mol. Cell / A Hedgehog-insensitive form of Patched provides evidence for direct long-range morphogen activity of Sonic hedgehog in the neural tube. by Briscoe (2001)
  25. 10.1002/(SICI)1521-1878(200006)22:6<499::AID-BIES1>3.0.CO;2-F / BioEssays / Life, death and Sonic hedgehog. by Britto (2000)
  26. 10.1016/S0959-4388(98)80064-0 / Curr. Opin. Neurobiol. / Signaling by Eph receptors and their ephrin ligands. by Bruckner (1998)
  27. 10.1128/MCB.15.4.2294 / Mol. Cell. Biol. / Proteolytic processing yields two secreted forms of Sonic hedgehog. by Bumcrot (1995)
  28. 10.1016/S0092-8674(00)81677-3 / Cell / Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells. by Burke (1999)
  29. 10.1016/S0925-4773(97)00656-4 / Mech. Dev. / Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. by Buscher (1997)
  30. 10.1002/j.1460-2075.1994.tb06768.x / EMBO J. / Targetted expression of the signalling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. by Capdevila (1994)
  31. 10.1002/j.1460-2075.1994.tb06236.x / EMBO J. / The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. by Capdevila (1994)
  32. 10.1242/dev.120.4.987 / Development / Subcellular localisation of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos. by Capdevila (1994)
  33. 10.1073/pnas.95.23.13630 / Proc. Natl. Acad. Sci. / Characterization of two patched receptors for the vertebrate hedgehog protein family. by Carpenter (1998)
  34. 10.1126/science.277.5323.228 / Science / Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis. by Carstea (1997)
  35. 10.1126/science.1064437 / Science / Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the secreted Hedgehog protein signal. by Chamoun (2001)
  36. 10.1242/dev.120.11.3339 / Development / Products, genetic linkage and limb patterning activity of a murine hedgehog gene. by Chang (1994)
  37. 10.1242/dev.128.12.2385 / Development / Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity. by Chen (2001)
  38. 10.1016/S0092-8674(00)81374-4 / Cell / Dual roles for patched in sequestering and transducing Hedgehog. by Chen (1996)
  39. 10.1073/pnas.95.5.2349 / Proc. Nat. Acad Sci. / Protein kinase A directly regulates the activity and proteolysis of Cubitus interruptus. by Chen (1998)
  40. 10.1242/dev.126.16.3607 / Development / Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling. by Chen (1999)
  41. 10.1038/383407a0 / Nature / Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. by Chiang (1996)
  42. 10.1006/dbio.1998.9103 / Dev. Biol. / Essential role for Sonic hedgehog during hair follicle morphogenesis. by Chiang (1999)
  43. 10.1006/dbio.2001.0346 / Dev. Biol. / Manifestation of the limb prepattern: Limb development in the absence of Sonic hedgehog function. by Chiang (2001)
  44. 10.1038/17611 / Nature / Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. by Chuang (1999)
  45. 10.1172/JCI11706 / J. Clin. Invest. / Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. by Chung (2001)
  46. 10.1095/biolreprod63.6.1825 / Biol. Reprod. / Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules. by Clark (2000)
  47. 10.1006/dbio.2001.0193 / Dev. Biol. / Hedgehog signalling is required for maintenance of myf5 and myoD expression and timely terminal differentiation in zebrafish adaxial myogenesis. by Coutelle (2001)
  48. 10.1016/S0960-9822(09)00452-7 / Curr. Biol. / Collier, a novel regulator of Drosophila head development, is expressed in a single mitotic domain. by Crozatier (1996)
  49. 10.1038/382452a0 / Nature / Induction of a specific muscle cell type by a novel hedgehog gene family member. by Currie (1996)
  50. 10.1242/dev.126.14.3089 / Development / Sonic hedgehog regulates the growth and patterning of the cerebellum. by Dahmane (1999)
  51. 10.1038/39918 / Nature / Activation of the transcription factor Gli1 and Sonic hedgehog signalling pathways in skin tumours. by Dahmane (1997)
  52. 10.1074/jbc.274.12.8143 / J. Biol. Chem. / Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. by Dai (1999)
  53. 10.1016/S0092-8674(00)80334-7 / Cell / Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm. by Dale (1997)
  54. 10.1038/35083601 / Nature / Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. by Dann (2001)
  55. 10.1006/dbio.1998.8992 / Dev. Biol. / Analysis of epithelial–mesenchymal interactions in the initial morphogenesis of the mammalian tooth. by Dassule (1998)
  56. 10.1242/dev.127.22.4775 / Development / Sonic hedgehog regulates growth and morphogenesis of the tooth. by Dassule (2000)
  57. 10.1126/science.290.5500.2295 / Science / Transmembrane molecular pump activity of Niemann-Pick C1 protein. by Davies (2000)
  58. 10.1016/S0092-8674(00)81668-2 / Cell / Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. by DeBose-Boyd (1999)
  59. 10.1074/jbc.M004055200 / J. Biol. Chem. / Smoothened activates Gαi-mediated signaling in frog melanophores. by DeCamp (2000)
  60. 10.1016/S0092-8674(00)00056-8 / Cell / Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. by Denef (2000)
  61. 10.1016/S0092-8674(01)00488-3 / Cell / Hedgehog signaling in germ cell migration. by Deshpande (2001)
  62. 10.1038/372175a0 / Nature / Cell interaction between compartments establishes the proximal–distal axis of Drosophila legs. by Diaz-Benjumea (1994)
  63. 10.1038/332604a0 / Nature / Two tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. by DiNardo (1988)
  64. 10.1242/dev.125.14.2533 / Development / Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. by Ding (1998)
  65. 10.1016/S0960-9822(99)80482-5 / Curr. Biol. / Mouse suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1. by Ding (1999)
  66. 10.1242/dev.126.11.2345 / Development / Dual role for Hedgehog in the regulation of the proneural gene atonal during ommatidia development. by Dominguez (1999)
  67. 10.1126/science.272.5268.1621 / Science / Sending and receiving the Hedgehog signal—Control by the Drosophila Gli protein Cubitus interruptus. by Dominguez (1996)
  68. 10.1242/dev.127.7.1337 / Development / A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling. by Drossopoulou (2000)
  69. 10.1006/dbio.1996.0087 / Dev. Biol. / Bone morphogenetic protein-2 (BMP-2) inhibits muscle development and promotes cartilage formation in chick limb bud cultures. by Duprez (1996)
  70. 10.1242/dev.125.3.495 / Development / Sonic hedgehog induces proliferation of committed skeletal muscle cells in the chick limb. by Duprez (1998)
  71. 10.1016/S0925-4773(99)00040-4 / Mech. Dev. / Sonic hedgehog (SHH) specifies muscle pattern at tissue and cellular chick level, in the chick limb bud. by Duprez (1999)
  72. 10.1242/dev.128.10.1717 / Development / Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. by Dyer (2001)
  73. 10.1016/0092-8674(93)90627-3 / Cell / Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. by Echelard (1993)
  74. 10.1006/dbio.2000.9918 / Dev. Biol. / Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene. by Eggenschwiler (2000)
  75. 10.1038/35084089 / Nature / Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. by Eggenschwiler (2001)
  76. 10.1242/dev.121.8.2337 / Development / Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis. by Ekker (1995)
  77. 10.1016/S0960-9822(95)00185-0 / Curr. Biol. / Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. by Ekker (1995)
  78. 10.1359/jbmr.2000.15.9.1659 / J. Bone Miner. Res. / Hedgehog proteins stimulate chondrogenic cell differentiation and cartilage formation. by Enomoto-Iwamoto (2000)
  79. 10.1016/0092-8674(95)90536-7 / Cell / Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube. by Ericson (1995)
  80. 10.1016/0092-8674(94)90009-4 / Cell / Patterning of mammalian somites by the surface ectoderm and the notochord: Evidence for scleretome induction by Sonic hedgehog/Vhh-1. by Fan (1994)
  81. 10.1242/dev.127.10.2133 / Development / Role of dHAND in the anterior–posterior polarization of the limb bud: Implications for the Sonic hedgehog pathway. by Fernandez-Teran (2000)
  82. 10.1016/S0960-9822(95)00129-1 / Curr. Biol. / Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog activity in Drosophila. by Fietz (1995)
  83. 10.1038/313284a0 / Nature / Isolation of a homeobox containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts. by Fjose (1985)
  84. 10.1242/dev.119.Supplement.115 / Development / Genetic analysis of hedgehog signalling in the Drosophila embryo. by Forbes (1993)
  85. 10.1242/dev.122.4.1125 / Development / hedgehog is required for the proliferation and specification of somatic cells during egg chamber assembly in Drosophila oogenesis. by Forbes (1996)
  86. 10.1073/pnas.96.20.10992 / Proc. Natl. Acad. Sci. / Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. by Fuse (1999)
  87. 10.1038/ng0996-78 / Nat. Genet. / The role of the human homolog of Drosophila patched in sporadic basal-cell carcinomas. by Gailani (1996)
  88. 10.1242/dev.127.24.5509 / Development / Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila. by Gallet (2000)
  89. 10.1006/dbio.2001.0283 / Dev. Biol. / Tbx1, a DiGeorge syndrome candidate gene, is regulated by Sonic hedgehog during pharyngeal arch development. by Garg (2001)
  90. 10.1242/dev.128.9.1599 / Development / Hedgehog signaling patterns the tracheal branches. by Glazer (2001)
  91. 10.1101/gad.10.3.301 / Genes & Dev. / Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by hedgehog. by Goodrich (1996)
  92. 10.1126/science.277.5329.1109 / Science / Altered neural cell fates and medulloblastoma in mouse patched mutants. by Goodrich (1997)
  93. 10.1006/dbio.1997.8644 / Dev. Biol. / Evidence for the involvement of the Gli gene family in embryonic mouse lung development. by Grindley (1997)
  94. 10.1006/dbio.2001.0336 / Dev. Biol. / The whereabouts of a morphogen: Direct evidence for short- and graded long-range activity of hedgehog signaling peptides. by Gritli-Linde (2001)
  95. 10.1242/dev.127.15.3283 / Development / Sonic hedgehog signaling at gastrula stages specifies ventral telencephalic cells in the chick embryo. by Gunhaga (2000)
  96. 10.1242/dev.120.11.3119 / Development / Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. by Gunther (1994)
  97. 10.1038/378212a0 / Nature / A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog. by Hall (1995)
  98. 10.1006/dbio.1997.8796 / Dev. Biology / The effect of pertussis toxin on zebrafish development: A possible role for inhibitory G-proteins in hedgehog signaling. by Hammerschmidt (1998)
  99. 10.1242/dev.125.15.2803 / Development / The Shh signalling pathway in tooth development: Defects in Gli2 and Gli3 mutants. by Hardcastle (1998)
  100. 10.1038/373709a0 / Nature / Growth and differentiation in the Drosophila eye coordinated by hedgehog. by Heberlein (1995)
  101. 10.1242/dev.127.22.4905 / Development / Regulation of pancreas development by hedgehog signaling. by Hebrok (2000)
  102. 10.1006/dbio.1997.8589 / Dev. Biol. / Sonic hedgehog participates in craniofacial morphogenesis and is down-regulated by teratogenic doses of retinoic acid. by Helms (1997)
  103. 10.1016/S0960-9822(00)00247-5 / Curr. Biol. / Three distinct roles for the engrailed gene in Drosophila wing development. by Hidalgo (1994)
  104. 10.1242/dev.110.1.291 / Development / Cell patterning in the Drosophila segment: Spatial regulation of the segment polarity gene patched. by Hidalgo (1990)
  105. 10.1006/mgme.1999.2882 / Mol. Genet. Metab. / Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network. by Higgins (1999)
  106. 10.1038/372461a0 / Nature / Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos. by Hooper (1994)
  107. 10.1016/S0092-8674(00)81362-8 / Cell / Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. by Hua (1996)
  108. 10.1016/S0092-8674(00)80114-2 / Cell / Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain. by Huang (1996)
  109. 10.1242/dev.125.19.3753 / Development / Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly. (1998)
  110. 10.1038/ng0393-241 / Nat. Genet. / A mouse model of Greig cephalopolysyndactyly syndrome: The extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. by Hui (1993)
  111. 10.1016/0896-6273(95)90062-4 / Neuron / Induction of midbrain dopaminergic neurons by Sonic hedgehog. by Hynes (1995)
  112. 10.1016/S0896-6273(00)80344-X / Neuron / Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. by Hynes (1997)
  113. 10.1038/71114 / Nat. Neurosci. / The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types. by Hynes (2000)
  114. 10.1006/dbio.2000.9775 / Dev. Biol / Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. by Incardona (2000)
  115. 10.1073/pnas.220251997 / Proc. Natl. Acad. Sci. / Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by patched-1. by Incardona (2000)
  116. 10.1016/S0959-437X(05)80080-2 / Curr. Opin. Genet. Dev. / Segment polarity genes and cell patterning within the Drosophila body segment. by Ingham (1991)
  117. 10.1016/S0959-437X(98)80067-1 / Curr. Opin. Genet. Dev. / The patched gene in development and cancer. by Ingham (1998)
  118. 10.1016/S0960-9822(95)00084-4 / Curr. Biol. / Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing. by Ingham (1995)
  119. 10.1242/dev.117.1.283 / Development / Regulation of wingless transcription in the Drosophila embryo. by Ingham (1993)
  120. 10.1038/353184a0 / Nature / Role of the Drosophila patched gene in positional signalling. by Ingham (1991)
  121. 10.1016/S0960-9822(00)00755-7 / Curr. Biol / Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. by Ingham (2000)
  122. 10.1242/dev.124.2.363 / Development / Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina. by Jensen (1997)
  123. 10.1038/35049541 / Nat. Rev. Genet. / Neuronal specification in the spinal cord: Inductive signals and transcriptional codes. by Jessell (2000)
  124. 10.1016/0092-8674(95)90510-3 / Cell / Protein kinase A and hedgehog signaling in Drosophila limb development. by Jiang (1995)
  125. 10.1016/0092-8674(94)90008-6 / Cell / Ectopic expression of Sonic hedgehog alters dorsal–ventral patterning of somites. by Johnson (1994)
  126. 10.1242/dev.121.12.4161 / Development / patched overexpression alters wing disc size and pattern: Transcriptional and post-transcriptional effects on hedgehog targets. by Johnson (1995)
  127. 10.1016/S1097-2765(00)00045-9 / Mol. Cell / In vivo functions of the Patched protein: Requirement of the C terminus for target gene inactivation but not Hedgehog sequestration. by Johnson (2000)
  128. 10.1242/dev.126.12.2611 / Development / Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. by Karlsson (1999)
  129. 10.1101/gad.13.4.388 / Genes & Dev. / Comparative synteny cloning of zebrafish you-too: Mutations in the Hedgehog target gli2 affect ventral forebrain patterning. by Karlstrom (1999)
  130. 10.1242/dev.127.3.543 / Development / Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. by Karp (2000)
  131. 10.1074/jbc.M010832200 / J. Biol. Chem. / The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. by Karpen (2001)
  132. 10.1128/MCB.20.23.9055-9067.2000 / Mol. Cell. Biol. / Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. by Kenney (2000)
  133. 10.1073/pnas.95.22.13036 / Proc. Natl. Acad. Sci. / Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. by Kim (1998)
  134. 10.1091/mbc.12.3.601 / Mol. Biol. Cell / Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. by Ko (2001)
  135. 10.1038/10084 / Nat. Cell Biol. / Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. by Kobayashi (1999)
  136. 10.1038/13031 / Nat. Cell Biol. / Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. by Kogerman (1999)
  137. 10.1242/dev.125.24.5079 / Development / Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic hedgehog. by Kohtz (1998)
  138. 10.1242/dev.128.12.2351 / Development / N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons. by Kohtz (2001)
  139. 10.1016/S0925-4773(00)00387-7 / Mech. Dev. / Zebrafish mutations in Gli-mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage. by Kondoh (2000)
  140. 10.1016/S0925-4773(00)00492-5 / Mech. Dev. / Some distal limb structures develop in mice lacking Sonic hedgehog signaling. by Kraus (2001)
  141. 10.1016/0092-8674(93)90628-4 / Cell / A functionally conserved homolog of the Drosophila segment polarity gene hedgehog is expressed in tissues with polarising activity in zebrafish embryos. by Krauss (1993)
  142. 10.1126/science.278.5345.1947 / Science / Mediation of Sonic hedgehog induced expression of COUP-TFII by a protein phosphatase. by Krishnan (1997)
  143. 10.1242/dev.128.5.743 / Development / Sonic hedgehog is a survival factor for hypaxial muscles during mouse development. by Kruger (2001)
  144. 10.1101/gad.14.15.1933 / Genes & Dev. / A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis. by Kuwabara (2000)
  145. 10.1242/dev.121.8.2349 / Development / Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage. by Lai (1995)
  146. 10.1016/S0896-6273(00)00121-5 / Neuron / Mesenchymal/epithelial induction mediates olfactory pathway formation. by LaMantia (2000)
  147. 10.1126/science.273.5275.663 / Science / PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. by Lanske (1996)
  148. 10.1016/0092-8674(94)90030-2 / Cell / Sonic hedgehog and Fgf-4 Act through a signalling cascade and feedback loop to integrate growth and patterning of the developing limb bud. by Laufer (1994)
  149. 10.1016/S0960-9822(01)00323-2 / Curr. Biol. / Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. by Lee (2001)
  150. {'key': '2021111507523830000_15.23.3059.150', 'first-page': '777', 'article-title': 'Secretion and localised transcription suggests a role in positional signalling for products of the segmentation gene hedgehog.', 'volume': '70', 'author': 'Lee', 'year': '1992', 'journal-title': 'Cell'} / Cell / Secretion and localised transcription suggests a role in positional signalling for products of the segmentation gene hedgehog. by Lee (1992)
  151. 10.1126/science.7985023 / Science / Autoproteolysis in hedgehog protein biogenesis. by Lee (1994)
  152. 10.1242/dev.124.13.2537 / Development / Gli1 is a target of sonic hedgehog that induces ventral neural-tube development. by Lee (1997)
  153. 10.1006/dbio.2001.0218 / Dev. Biol. / An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development. by Lee (2001)
  154. 10.1146/annurev.neuro.22.1.261 / Annu. Rev. Neurosci. / The specification of dorsal cell fates in the vertebrate central nervous system. by Lee (1999)
  155. 10.1016/0092-8674(95)90477-8 / Cell / A molecular pathway determining left–right asymmetry in chick embryogenesis. by Levin (1995)
  156. 10.1523/JNEUROSCI.17-16-06277.1997 / J. Neurosci. / Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro. by Levine (1997)
  157. 10.1006/dbio.1998.9169 / Dev. Biol. / Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling. by Lewis (1999)
  158. 10.1006/dbio.1999.9519 / Dev. Biol. / Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling. by Lewis (1999)
  159. 10.1016/S0092-8674(01)00369-5 / Cell / Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. by Lewis (2001)
  160. 10.1074/jbc.273.41.26265 / J. Biol. Chem. / The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate. by Lind (1998)
  161. 10.1038/79916 / Nat. Neurosci. / Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. by Litingtung (2000)
  162. 10.1038/1717 / Nat. Genet. / Sonic hedgehog is essential to foregut development. by Litingtung (1998)
  163. 10.1126/science.277.5323.232 / Science / Murine model of Niemann-Pick C diseases: Mutation in a cholesterol homeostasis gene. by Loftus (1997)
  164. 10.1016/S0896-6273(00)80897-1 / Neuron / Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. by Lu (2000)
  165. 10.1242/dev.121.10.3267 / Development / Midline signalling is required for Pax gene regulation and patterning of the eyes. by Macdonald (1995)
  166. 10.1073/pnas.93.18.9346 / Proc. Natl. Acad. Sci. / Regulation of patched by sonic hedgehog in the developing neural tube. by Marigo (1996)
  167. 10.1038/384176a0 / Nature / Biochemical evidence that patched is the hedgehog receptor. by Marigo (1996)
  168. 10.1006/dbio.1996.0300 / Dev. Biol. / Sonic hedgehog differentially regulates expression of Gli and Gli3 during limb development. by Marigo (1996)
  169. 10.1242/dev.122.4.1225 / Development / Conservation in hedgehog signaling: Induction of a chicken patched homolog by Sonic hedgehog in the developing limb. by Marigo (1996)
  170. 10.1038/375322a0 / Nature / Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. by Marti (1995)
  171. 10.1016/S0960-9822(01)00178-6 / Curr. Biol. / The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking. by Martin (2001)
  172. 10.1242/dev.103.1.157 / Development / Role of segment polarity gene in the definition and maintenance of cell states in the Drosophila embryo. by Martinez Arias (1988)
  173. 10.1101/gad.14.6.627 / Genes & Dev. / Controlling TGF-β signaling. by Massague (2000)
  174. 10.1097/00001756-200002280-00030 / Neuroreport / Co-localization of patched and activated sonic hedgehog to lysosomes in neurons. by Mastronardi (2000)
  175. 10.1101/gad.9.13.1645 / Genes & Dev. / A duplicated zone of polarizing activity in polydactylous mouse mutants. by Masuya (1995)
  176. 10.1242/dev.125.15.2759 / Development / Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. by Matise (1998)
  177. 10.1016/0092-8674(92)90222-X / Cell / The midbrain–hindbrain phenotype of Wnt-1−/Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. by McMahon (1992)
  178. 10.1016/S0092-8674(00)80592-9 / Cell / Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. by Methot (1999)
  179. 10.1242/dev.127.18.4001 / Development / Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. (2000)
  180. 10.1242/dev.128.5.733 / Development / An absolute requirement for Cubitus interruptus in Hedgehog signaling. (2001)
  181. 10.1126/science.285.5426.403 / Science / Differences in left–right axis pathways in mouse and chick: Functions of FGF8 and SHH. by Meyers (1999)
  182. 10.1016/S0960-9822(00)00695-3 / Curr. Biol. / CHE-14, a protein with a sterol-sensing domain, is required for apical sorting in C. elegans ectodermal epithelial cells. by Michaux (2000)
  183. 10.1016/S0925-4773(01)00414-2 / Mech. Dev. / Shh and Ptc are associated with taste bud maintenance in the adult mouse. by Miura (2001)
  184. 10.1242/dev.124.1.113 / Development / Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. by Mo (1997)
  185. 10.1093/genetics/120.4.1061 / Genetics / Requirements for hedgehog, a segment polarity gene, in patterning larval and adult cuticle of Drosophila. by Mohler (1988)
  186. 10.1242/dev.115.4.957 / Development / Molecular organisation and embryonic expression of the hedgehog gene involved in cell–cell communication in segmental patterning in Drosophila. by Mohler (1992)
  187. 10.1242/dev.127.1.55 / Development / Activation of knot (kn) specifies the 3–4 intervein region in the Drosophila wing. by Mohler (2000)
  188. 10.1016/S0960-9822(98)70227-1 / Curr. Biol. / Molecular interactions between three members of the Drosophila Hedgehog signalling pathway: Suppressor of fused links the ser–thr kinase Fused and the transcription factor Cubitus interruptus. by Monnier (1998)
  189. 10.1016/S1097-2765(01)00223-4 / Mol. Cell. / BMP4 plays a key role in left–right patterning in chick embryos by maintaining Sonic hedgehog asymmetry. by Monsoro-Burq (2001)
  190. 10.1006/dbio.1998.8969 / Dev. Biol. / Stage-specific effects of sonic hedgehog expression in the epidermis. by Morgan (1998)
  191. 10.1038/1711 / Nat. Genet. / Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. by Motoyama (1998)
  192. 10.1038/ng0298-104 / Nat. Genet. / Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. by Motoyama (1998)
  193. 10.1016/0925-4773(95)00397-J / Mech. Dev / The Drosophila Cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. by Motzny (1995)
  194. 10.1006/dbio.2000.9862 / Dev. Biol. / A gain-of-function mutant of patched dissects different responses to the hedgehog gradient. by Mullor (2000)
  195. 10.1242/dev.124.6.1227 / Development / Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning. by Mullor (1997)
  196. 10.1101/gad.9.23.2911 / Genes & Dev. / Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. by Munsterberg (1995)
  197. 10.1016/S0960-9822(99)80018-9 / Curr. Biol / Sonic hedgehog signaling by the patched–smoothened receptor complex. by Murone (1999)
  198. 10.1038/35010610 / Nat. Cell Biol. / Gli regulation by the opposing activities of fused and suppressor of fused. by Murone (2000)
  199. 10.1101/gad.13.2.225 / Genes & Dev. / Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. by Murtaugh (1999)
  200. 10.1006/bbrc.1997.7156 / Biochem. Biophys. Res. Commun. / Induction of osteogenic differentiation by hedgehog proteins. by Nakamura (1997)
  201. 10.1016/S0092-8674(00)81114-9 / Cell / Direct and long-range action of a dpp morphogen gradient. by Nellen (1996)
  202. 10.1242/dev.128.4.527 / Development / Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain. by Nery (2001)
  203. 10.1074/jbc.274.14.9627 / J. Biol. Chem. / The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo. by Neufeld (1999)
  204. 10.1126/science.289.5487.2137 / Science / Patterning of the zebrafish retina by a wave of sonic hedgehog activity. by Neumann (2000)
  205. 10.1242/dev.126.21.4817 / Development / Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity. by Neumann (1999)
  206. 10.1038/371609a0 / Nature / A positive feedback loop coordinates growth and patterning in the vertebrate limb. by Niswander (1994)
  207. 10.1073/pnas.96.20.11235 / Proc. Natl. Acad. Sci. / Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. by Nohturfft (1999)
  208. 10.1242/jcs.113.15.2695 / J. Cell Sci. / Slow muscle induction by Hedgehog signalling in vitro. by Norris (2000)
  209. 10.1038/287795a0 / Nature / Mutations affecting segment number and polarity in Drosophila. by Nüsslein-Volhard (1980)
  210. 10.1093/hmg/8.9.1683 / Hum. Mol. Genet. / Expression of the Sonic hedgehog (SHH) gene during early human development and phenotypic expression of new mutations causing holoprosencephaly. by Odent (1999)
  211. 10.1038/25533 / Nature / Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. by Ohlmeyer (1998)
  212. 10.1006/mcne.1999.0755 / Mol. Cell Neurosci. / Modulation of early but not later stages of programmed cell death in embryonic avian spinal cord by sonic hedgehog. by Oppenheim (1999)
  213. 10.1242/dev.126.11.2419 / Development / Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors. by Orentas (1999)
  214. 10.1016/S1074-7613(00)00019-4 / Immunity / Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. by Outram (2000)
  215. 10.1242/dev.121.6.1885 / Development / Control of epithelial morphogenesis by cell signaling and integrin molecules in the Drosophila foregut. by Pankratz (1995)
  216. 10.1242/dev.127.8.1593 / Development / Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. by Park (2000)
  217. 10.1016/S0896-6273(01)80030-1 / Neuron / Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. by Parmantier (1999)
  218. 10.1016/S0925-4773(01)00427-0 / Mech. Dev. / Comparative biological responses to human Sonic, Indian, and Desert hedgehog. by Pathi (2001)
  219. 10.1006/dbio.1999.9335 / Dev. Biol. / Vertebrate homologs of Drosophila Suppressor of fused interact with the Gli family of transcriptional regulators. by Pearse (1999)
  220. 10.1016/S0960-9822(98)70446-4 / Curr. Biol. / Sonic hedgehog regulates branching morphogenesis in the mammalian lung. by Pepicelli (1998)
  221. 10.1074/jbc.273.22.14037 / J. Biol. Chem. / Identification of a palmitic acid-modified form of human Sonic hedgehog. by Pepinsky (1998)
  222. 10.1016/0959-437X(95)90055-L / Curr. Opin. Genet. Dev. / The role of the notochord and floor plate in inductive interactions. by Placzek (1995)
  223. 10.1006/dbio.1999.9229 / Dev. Biol. / Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium. by Podlasek (1999)
  224. 10.1038/89083 / Nat. Med. / The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. by Pola (2001)
  225. 10.1016/S0925-4773(96)00595-3 / Mech. Dev. / Induction of oligodendrocyte progenitors in the trunk neural tube by ventralizing signals: Effects of notochord and floor plate grafts, and of sonic hedgehog. by Poncet (1996)
  226. 10.1242/dev.128.9.1481 / Development / Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation. by Pons (2001)
  227. 10.1016/0092-8674(85)90306-X / Cell / The engrailed locus of Drosophila: Structural analysis of an embryonic transcript. by Poole (1985)
  228. 10.1038/374363a0 / Nature / The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. by Porter (1995)
  229. 10.1016/S0092-8674(00)80074-4 / Cell / Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. by Porter (1996)
  230. 10.1126/science.274.5285.255 / Science / Cholesterol modification of hedgehog signaling proteins in animal development. by Porter (1996)
  231. 10.1093/genetics/132.3.725 / Genetics / Characterisation of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster. by Préat (1992)
  232. 10.1242/dev.126.19.4331 / Development / Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. by Price (1999)
  233. 10.1006/dbio.1996.0142 / Dev. Biol. / Determination of neuroepithelial cell fate: Induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. by Pringle (1996)
  234. 10.1101/SQB.1997.062.01.027 / Cold Spring Harbor Symp. / The smoothened gene and Hedgehog signal transduction in Drosophila and vertebrate development. by Quirk (1997)
  235. 10.1242/dev.127.12.2763 / Development / Hedgehog signals regulate multiple aspects of gastrointestinal development. by Ramalho-Santos (2000)
  236. 10.1016/S1097-2765(00)00046-0 / Mol. Cell / Hedgehog signal transduction in the posterior compartment of the Drosophila wing imaginal disc. by Ramirez-Weber (2000)
  237. 10.1016/0092-8674(93)90626-2 / Cell / Sonic hedgehog mediates the polarizing activity of the ZPA. by Riddle (1993)
  238. 10.1074/jbc.274.17.12049 / J. Biol. Chem. / Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains. by Rietveld (1999)
  239. 10.1016/0092-8674(87)90038-9 / Cell / The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. by Rijsewijk (1987)
  240. 10.1016/S0092-8674(00)80331-1 / Cell / Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein Costal2. by Robbins (1997)
  241. 10.1242/dev.121.10.3163 / Development / Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. by Roberts (1995)
  242. 10.1016/0092-8674(94)90514-2 / Cell / Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. by Roelink (1994)
  243. 10.1016/0092-8674(95)90397-6 / Cell / Floor plate and motor neuron induction by different concentrations of the amino terminal cleavage product of Sonic hedgehog autoproteolysis. by Roelink (1995)
  244. 10.1038/ng1196-357 / Nat. Genet. / Mutations in the human Sonic hedgehog gene cause holoprosencephaly. by Roessler (1996)
  245. 10.1523/JNEUROSCI.19-20-08954.1999 / J. Neurosci. / Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. by Rowitch (1999)
  246. 10.1016/S0960-9822(01)00402-X / Curr. Biol. / Hedgehog signalling pathway is essential for pancreas specification in the zebrafish embryo. by Roy (2001)
  247. 10.1242/dev.125.12.2203 / Development / Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. by Ruiz i Altaba (1998)
  248. 10.1242/dev.126.14.3205 / Development / Gli proteins encode context-dependent positive and negative functions: Implications for development and disease. (1999)
  249. 10.1242/dev.117.2.677 / Development / A role for wingless in the segmental gradient of Drosophila? by Sampedro (1993)
  250. 10.1242/dev.127.22.4811 / Development / Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. by Sanz-Ezquerro (2000)
  251. 10.1242/dev.124.7.1313 / Development / A binding-site for Gli proteins is essential for Hnf3b floor plate enhancer activity in transgenics and can respond to Shh in vitro. by Sasaki (1997)
  252. 10.1242/dev.126.17.3915 / Development / Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling. by Sasaki (1999)
  253. 10.1172/JCI7691 / J. Clin. Invest. / Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog. by Sato (1999)
  254. 10.1006/dbio.1999.9214 / Dev. Biol. / Regulation of left–right asymmetries in the zebrafish by Shh and BMP4. by Schilling (1999)
  255. 10.1101/gad.10.18.2302 / Genes & Dev. / Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. by Schnepp (1996)
  256. 10.1007/s004270050225 / Dev. Genes Evol. / The evolution of the hedgehog gene family in chordates: Insights from amphioxus hedgehog. by Shimeld (1999)
  257. 10.1242/dev.128.8.1369 / Development / Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: Oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism. by Soula (2001)
  258. 10.1016/S0960-9822(98)70443-9 / Curr. Biol. / Sonic hedgehog signaling is essential for hair development. by St-Jacques (1998)
  259. 10.1101/gad.13.16.2072 / Genes & Dev. / Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. by St-Jacques (1999)
  260. 10.1074/jbc.C000043200 / J. Biol. Chem. / Identification of a tetrameric hedgehog signaling complex. by Stegman (2000)
  261. 10.1006/dbio.2000.9629 / Dev. Biol. / Function for Hedgehog genes in zebrafish retinal development. by Stenkamp (2000)
  262. 10.1038/ng0996-25 / Nat. Genet. / The EXT2 multiple exostoses gene defines a family of putative tumor suppressor genes. by Stickens (1996)
  263. 10.1038/384129a0 / Nature / The tumor-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. by Stone (1996)
  264. 10.1242/dev.124.22.4697 / Development / A hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. by Strigini (1997)
  265. 10.1242/dev.124.11.2143 / Development / Hedgehog organizes the pattern and polarity of epidermal cells in the Drosophila abdomen. by Struhl (1997)
  266. 10.1016/S0960-9822(01)00179-8 / Curr. Biol / Mutations in the sterol sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. by Strutt (2001)
  267. 10.1242/dev.127.9.1971 / Development / The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. by Sukegawa (2000)
  268. 10.1016/S0074-7696(08)60149-7 / Int. Rev. Cytol. / Fibroblast growth factors as multifunctional signaling factors. by Szebenyi (1999)
  269. 10.1016/0092-8674(94)90175-9 / Cell / Hedgehog is a signalling protein with a key role in patterning Drosophila imaginal discs. by Tabata (1994)
  270. 10.1101/gad.6.12b.2635 / Genes & Dev. / The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. by Tabata (1992)
  271. 10.1016/0092-8674(91)90612-3 / Cell / Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development. by Tabin (1991)
  272. 10.1038/35077219 / Nature / The Hedgehog and Wnt signalling pathways in cancer. by Taipale (2001)
  273. 10.1038/35023008 / Nature / Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. by Taipale (2000)
  274. 10.1016/S1097-2765(00)80403-7 / Mol. Cell / Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. by Tanimoto (2000)
  275. 10.1016/0378-1119(93)90392-G / Gene / Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell–cell communication. by Tashiro (1993)
  276. 10.1016/0925-4773(93)90101-3 / Mech. Dev. / Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo. by Taylor (1993)
  277. 10.1021/bi002487u / Biochemistry / Enhanced potency of human Sonic hedgehog by hydrophobic modification. by Taylor (2001)
  278. 10.1242/dev.125.11.2019 / Development / Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages. by Teillet (1998)
  279. 10.1016/S0092-8674(00)00199-9 / Cell / Dpp gradient formation in the Drosophila wing imaginal disc. by Teleman (2000)
  280. 10.1016/S1097-2765(00)80214-2 / Mol. Cell / Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. by Thé (1999)
  281. 10.1242/dev.126.18.4039 / Development / Differential requirements of the Fused kinase for Hedgehog signalling in the Drosophila embryo. by Therond (1999)
  282. 10.1210/endo.142.3.8007 / Endocrinology / Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic β-cells. by Thomas (2001)
  283. 10.1002/(SICI)1097-0177(199610)207:2<157::AID-AJA4>3.0.CO;2-G / Dev. Dyn. / Sonic hedgehog in feather morphogenesis: Induction of mesenchymal condensation and association with cell death. by Ting-Berreth (1996)
  284. 10.1006/dbio.1999.9509 / Dev. Biol. / Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). by Tole (2000)
  285. 10.1242/dev.128.3.377 / Development / Hedgehog signaling is required for pituitary gland development. by Treier (2001)
  286. 10.1073/pnas.96.20.11376 / Proc. Natl. Acad. Sci. / Multiple left–right asymmetry defects in Shh −/− mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1. by Tsukui (1999)
  287. 10.1086/321210 / Am. J. Hum. Genet. / A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy. by Umehara (2000)
  288. 10.1038/382547a0 / Nature / smoothened encodes a serpentine protein required for hedgehog signaling. by van den Heuvel (1996)
  289. 10.1242/dev.123.1.153 / Development / Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. by van Eeden (1996)
  290. 10.1016/S0960-9822(00)80118-9 / Curr. Biol / Pharyngeal arch patterning in the absence of neural crest. by Veitch (1999)
  291. 10.1016/S0960-9822(99)80285-1 / Curr. Biol. / The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing. by Vervoort (1999)
  292. 10.1016/S0002-9297(07)62934-6 / Am. J. Hum. Genet. / The sonic hedgehog–patched–gli pathway in human development and disease. by Villavicencio (2000)
  293. 10.1016/S0960-9822(00)80054-8 / Curr. Biol. / Distinct and regulated activities of human Gli proteins in Drosophila. by von Mering (1999)
  294. 10.1126/science.273.5275.613 / Science / Indian hedgehog and parathyroid hormone-related protein regulate the rate of cartilage differentiation. by Vortkamp (1996)
  295. 10.1016/S0960-9822(99)80195-X / Curr. Biol. / Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum. by Wallace (1999)
  296. 10.1242/dev.126.13.2901 / Development / A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve. by Wallace (1999)
  297. 10.1016/S0092-8674(00)80678-9 / Cell / Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. by Wang (2000)
  298. 10.1101/gad.843900 / Genes & Dev. / Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. by Wang (2000)
  299. 10.1038/nm1195-1184 / Nat. Med. / Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein. by Wang (1995)
  300. 10.1242/dev.126.22.5097 / Development / The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels. by Wang (1999)
  301. 10.1242/dev.127.14.3131 / Development / Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. (2000)
  302. 10.1242/dev.127.5.1131 / Development / Control of chick tectum territory along dorsoventral axis by Sonic hedgehog. by Watanabe (2000)
  303. 10.1016/S0896-6273(00)80682-0 / Neuron / Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. by Wechsler-Reya (1999)
  304. 10.1242/dev.126.9.1985 / Development / Hox genes differentially regulate Serrate to generate segment-specific structures. by Wiellette (1999)
  305. 10.1097/00001756-200010200-00011 / Neuroreport / Sonic hedgehog promotes proliferation and tyrosine hydroxylase induction of postnatal sympathetic cells in vitro. by Williams (2000)
  306. 10.1146/annurev.cellbio.14.1.59 / Annu. Rev. Cell Dev. Biol. / Mechanisms of Wnt signaling in development. by Wodarz (1998)
  307. 10.1093/genetics/158.3.1189 / Genetics / Genetic analysis of the Drosophila Gsα gene. by Wolfgang (2001)
  308. 10.1038/34201 / Nature / Activating smoothened mutations in sporadic basal-cell carcinoma. by Xie (1998)
  309. 10.1242/dev.124.21.4393 / Development / Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. by Yang (1997)
  310. 10.1016/S0092-8674(00)81437-3 / Cell / FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. by Ye (1998)
  311. 10.1006/excr.2001.5161 / Exp. Cell. Res. / Direct inhibition of Indian hedgehog expression by parathyroid hormone (PTH)/PTH-related peptide and up-regulation by retinoic acid in growth plate chondrocyte cultures. by Yoshida (2001)
  312. 10.1242/dev.121.8.2265 / Development / Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. by Zecca (1995)
  313. 10.1038/35079648 / Nature / A freely diffusible form of Sonic hedgehog mediates long-range signalling. by Zeng (2001)
  314. 10.1242/dev.128.6.943 / Development / Regulation of retinal ganglion cell production by Sonic hedgehog. by Zhang (2001)
  315. 10.1006/dbio.2000.0195 / Dev. Biol. / Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis. (2001)
  316. 10.1016/S0092-8674(01)00385-3 / Cell / Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. by Zhang (2001)
  317. 10.1242/dev.127.10.2165 / Development / Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling. by Zhang (2000)
  318. 10.1242/dev.127.7.1431 / Development / A new function of BMP4: Dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ. by Zhang (2000)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 7:59 p.m.)
Deposited 3 years, 9 months ago (Nov. 15, 2021, 10:59 a.m.)
Indexed 2 days, 16 hours ago (Aug. 26, 2025, 2:50 a.m.)
Issued 23 years, 8 months ago (Dec. 1, 2001)
Published 23 years, 8 months ago (Dec. 1, 2001)
Published Online 23 years, 8 months ago (Dec. 1, 2001)
Published Print 23 years, 8 months ago (Dec. 1, 2001)
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@article{Ingham_2001, title={Hedgehog signaling in animal development: paradigms and principles}, volume={15}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.938601}, DOI={10.1101/gad.938601}, number={23}, journal={Genes &amp; Development}, publisher={Cold Spring Harbor Laboratory}, author={Ingham, Philip W. and McMahon, Andrew P.}, year={2001}, month=dec, pages={3059–3087} }