DOI: 10.1101/gad.917101. biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila

biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila

10.1101/gad.917101

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The subdivision of the lateral mesoderm into a visceral (splanchnic) and a somatic layer is a crucial event during early mesoderm development in both arthropod and vertebrate embryos. InDrosophila, this subdivision leads to the differential development of gut musculature versus body wall musculature. Here we report that biniou, the sole Drosophila representative of the FoxF subfamily of forkhead domain genes, has a key role in the development of the visceral mesoderm and the derived gut musculature.biniou expression is activated in the trunk visceral mesoderm primordia downstream of dpp, tinman, andbagpipe and is maintained in all types of developing gut muscles. We show that biniou activity is essential for maintaining the distinction between splanchnic and somatic mesoderm and for differentiation of the splanchnic mesoderm into midgut musculature.biniou is required not only for the activation of differentiation genes that are expressed ubiquitously in the trunk visceral mesoderm but also for the expression of dpp in parasegment 7, which governs proper midgut morphogenesis. Activation ofdpp is mediated by specific Biniou binding sites in adpp enhancer element, which suggests that Biniou serves as a tissue-specific cofactor of homeotic gene products in visceral mesoderm patterning. Based upon these and other data, we propose that the splanchnic mesoderm layers in Drosophila and vertebrate embryos are homologous structures whose development into gut musculature and other visceral organs is critically dependent on FoxF genes.

Bibliography

Zaffran, S., KÃ¼chler, A., Lee, H.-H., & Frasch, M. (2001). biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila. Genes & Development, 15(21), 2900â2915.

Authors 4

Stephane Zaffran (first)
Axel Küchler (additional)
Hsiu-Hsiang Lee (additional)
Manfred Frasch (additional)

References 49 Referenced 133

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Dates

Type	When
Created	3 years, 9 months ago (Nov. 15, 2021, 10:51 a.m.)
Deposited	3 years, 9 months ago (Nov. 15, 2021, 10:53 a.m.)
Indexed	1 month ago (July 30, 2025, 10:24 a.m.)
Issued	23 years, 10 months ago (Nov. 1, 2001)
Published	23 years, 10 months ago (Nov. 1, 2001)
Published Online	23 years, 10 months ago (Nov. 1, 2001)
Published Print	23 years, 10 months ago (Nov. 1, 2001)

Funders 0

None

BibTeX

@article{Zaffran_2001, title={biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila}, volume={15}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.917101}, DOI={10.1101/gad.917101}, number={21}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Zaffran, Stephane and Küchler, Axel and Lee, Hsiu-Hsiang and Frasch, Manfred}, year={2001}, month=nov, pages={2900–2915} }

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