DOI: 10.1101/gad.907901. Regulation of <i>cyclin D2</i> gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the <i>cyclin D2</i> promoter

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter

10.1101/gad.907901

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

Myc oncoproteins promote cell cycle progression in part through the transcriptional up-regulation of the cyclin D2 gene. We now show that Myc is bound to the cyclin D2 promoter in vivo. Binding of Myc induces cyclin D2 expression and histone acetylation at a single nucleosome in a MycBoxII/TRRAP-dependent manner. Down-regulation of cyclin D2 mRNA expression in differentiating HL60 cells is preceded by a switch of promoter occupancy from Myc/Max to Mad/Max complexes, loss of TRRAP binding, increased HDAC1 binding, and histone deacetylation. Thus, recruitment of TRRAP and regulation of histone acetylation are critical for transcriptional activation by Myc.

Bibliography

Bouchard, C., Dittrich, O., Kiermaier, A., Dohmann, K., Menkel, A., Eilers, M., & LÃ¼scher, B. (2001). Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Genes & Development, 15(16), 2042â2047.

Authors 7

Caroline Bouchard (first)
Oliver Dittrich (additional)
Astrid Kiermaier (additional)
Karen Dohmann (additional)
Annette Menkel (additional)
Martin Eilers (additional)
Bernhard Lüscher (additional)

References 28 Referenced 266

10.1038/387049a0
10.1016/S0304-419X(01)00020-8
10.1101/gad.7.11.2110
10.1128/MCB.16.10.5772 / Mol. Cell. Biol. / Mad proteins contain a dominant transcription repression domain. by Ayer (1996)
10.1093/emboj/18.19.5321
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10.1146/annurev.cellbio.16.1.653
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{'key': '2021111507415170000_15.16.2042.12', 'first-page': '5922', 'article-title': 'Identification of c-myc responsive genes using rat cDNA microarray .', 'volume': '60', 'author': 'Guo', 'year': '2000', 'journal-title': 'Cancer Res.'} / Cancer Res. / Identification of c-myc responsive genes using rat cDNA microarray . by Guo (2000)
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{'key': '2021111507415170000_15.16.2042.26', 'first-page': '455', 'article-title': 'Mapping DNA target sites of chromatin proteins in vivo by formaldehyde crosslinking.', 'volume': '119', 'author': 'Strutt', 'year': '1999', 'journal-title': 'Methods Mol. Biol.'} / Methods Mol. Biol. / Mapping DNA target sites of chromatin proteins in vivo by formaldehyde crosslinking. by Strutt (1999)
10.1101/gad.12.24.3803
10.1073/pnas.071043198

Dates

Type	When
Created	23 years ago (July 26, 2002, 8 p.m.)
Deposited	3 years, 9 months ago (Nov. 15, 2021, 10:44 a.m.)
Indexed	1 month, 3 weeks ago (July 2, 2025, 2:31 p.m.)
Issued	24 years ago (Aug. 15, 2001)
Published	24 years ago (Aug. 15, 2001)
Published Online	24 years ago (Aug. 15, 2001)
Published Print	24 years ago (Aug. 15, 2001)

Funders 0

None

BibTeX

@article{Bouchard_2001, title={Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter}, volume={15}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.907901}, DOI={10.1101/gad.907901}, number={16}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Bouchard, Caroline and Dittrich, Oliver and Kiermaier, Astrid and Dohmann, Karen and Menkel, Annette and Eilers, Martin and Lüscher, Bernhard}, year={2001}, month=aug, pages={2042–2047} }

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