DOI: 10.1101/gad.9.21.2598. The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.

10.1101/gad.9.21.2598

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The Notch protein (N) acts as a transmembrane receptor for intercellular signals controlling cell fate choices in vertebrates and invertebrates. The signal of N activation may be transduced directly from the cell surface into the nucleus by an evolutionarily conserved transcription factor, Suppressor of Hairless [Su(H)], by its regulated nuclear import. Su(H) is shown here to play a direct role in the immediate response of the genome to N signaling in Drosophila. First, Su(H) mutant embryos derived from mutant germ-line clones exhibited a "neurogenic" phenotype of neural hypertrophy similar to the N phenotype. Second, the lack of N lateral signaling in these Su(H) mutant embryos was associated with a failure to express the m5 and m8 genes from the Enhancer of split Complex [E(spl)-C]. Finally, the Su(H) protein bound to the regulatory sequences of the E(spl)-C m5 and m8 genes, and these binding sites were required for the activation of the m5 and m8 promoters in the ventral neuroectoderm. The expression of the E(spl)-C m8 gene was found to be similarly regulated by Su(H) during wing imaginal disc development. Thus, the transcriptional activation of these E(spl)-C genes by Su(H) appears to be a direct and relatively general response to the activation of N. However, we also present evidence indicating that N signals in an Su(H)-independent manner during mesectoderm formation.

Bibliography

Lecourtois, M., & Schweisguth, F. (1995). The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes & Development, 9(21), 2598â2608.

Authors 2

M Lecourtois (first)
F Schweisguth (additional)

References 56 Referenced 374

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Dates

Type	When
Created	18 years, 3 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 9:42 p.m.)
Indexed	2 weeks, 4 days ago (Aug. 19, 2025, 6:10 a.m.)
Issued	29 years, 10 months ago (Nov. 1, 1995)
Published	29 years, 10 months ago (Nov. 1, 1995)
Published Online	29 years, 10 months ago (Nov. 1, 1995)
Published Print	29 years, 10 months ago (Nov. 1, 1995)

Funders 0

None

BibTeX

@article{Lecourtois_1995, title={The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.}, volume={9}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.9.21.2598}, DOI={10.1101/gad.9.21.2598}, number={21}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Lecourtois, M and Schweisguth, F}, year={1995}, month=nov, pages={2598–2608} }

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