p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.
10.1101/gad.9.2.204
Crossref journal-article
Cold Spring Harbor Laboratory
Genes & Development (246)
Abstract

Transforming growth factor beta 1 (TGF-beta 1) can cause a cell-cycle arrest in G1. Inhibition of cyclin-dependent kinase 4 (cdk4) synthesis plays a significant role in the mechanism by which this cytokine causes G1 growth arrest. Deregulated expression of cdk4 confers resistance to TGF-beta 1. Here, we show that TGF-beta 1 down-regulates cdk4 expression by inhibiting its translation. Moreover, mutant p53 confers resistance to TGF-beta 1 by interfering with the down-regulation of cdk4 in response to the cytokine. In contrast, we demonstrate that wild-type p53 represses the translation of CDK4. Regulation of cdk4 synthesis by both p53 and TGF-beta 1 is mediated by the 5'-untranslated region of the CDK4 message. Thus, regulation of CDK4 translation may be involved in control of G1 progression by p53.

Bibliography

Ewen, M. E., Oliver, C. J., Sluss, H. K., Miller, S. J., & Peeper, D. S. (1995). p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest. Genes & Development, 9(2), 204–217.

Authors 5
  1. M E Ewen (first)
  2. C J Oliver (additional)
  3. H K Sluss (additional)
  4. S J Miller (additional)
  5. D S Peeper (additional)
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Dates
Type When
Created 18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited 3 years, 9 months ago (Nov. 14, 2021, 9:29 p.m.)
Indexed 4 months, 4 weeks ago (March 30, 2025, 10:51 p.m.)
Issued 30 years, 7 months ago (Jan. 15, 1995)
Published 30 years, 7 months ago (Jan. 15, 1995)
Published Online 30 years, 7 months ago (Jan. 15, 1995)
Published Print 30 years, 7 months ago (Jan. 15, 1995)
Funders 0

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@article{Ewen_1995, title={p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.}, volume={9}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.9.2.204}, DOI={10.1101/gad.9.2.204}, number={2}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Ewen, M E and Oliver, C J and Sluss, H K and Miller, S J and Peeper, D S}, year={1995}, month=jan, pages={204–217} }