DOI: 10.1101/gad.9.19.2373. Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis.

Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis.

10.1101/gad.9.19.2373

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The mechanisms that underlie the segregation of muscle founder cells in the Drosophila embryo are undefined. We show that the proneural gene lethal of scute (l'sc) is expressed in clusters of cells in the somatic mesoderm, from which individual muscle progenitors are singled out by progressive restriction of l'sc expression. Coexpression of l'sc and S59 (a putative muscle identity gene) in a subset of muscle progenitors shows that muscle founders are produced by division of muscle progenitors. In neurogenic mutant embryos the restriction of l'sc expression fails and all cells in a cluster coexpress l'sc and S59. Loss-of-function and overexpression phenotypes indicate a role for l'sc in the segregation of muscle progenitors and the formation of the muscle pattern.

Bibliography

Carmena, A., Bate, M., & JimÃ©nez, F. (1995). Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis. Genes & Development, 9(19), 2373â2383.

Authors 3

A Carmena (first)
M Bate (additional)
F Jiménez (additional)

References 38 Referenced 168

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Bate, M. 1993. The mesoderm and its derivatives. In The development of Drosophila melanogaster. (ed. M. Bate and A. Martínez Arias), pp. 1013–1090. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, New York.
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10.1242/dev.113.1.79 / Development / Cells with persistent twist expression are the embryonic precursors of adult muscles in Drosophila. (1991)
Bate, M., Rushton, E. and Frasch. M. 1993. A dual requirement for neurogenic genes in Drosophila myogenesis. Suppl. Development 149–161. (10.1242/dev.119.Supplement.149)
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Goodman, C.S. and C.Q. Doe. 1993. Embryonic development of the Drosophila central nervous system. In The Development of Drosophila melanogaster. (ed. M. Bate and A. Martínez Arias), pp. 1131–1206. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
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10.1242/dev.118.3.1003 / Development / Molecular characterization of the lethal of scute genetic function. (1993)
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10.1101/gad.5.12b.2481

Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 9:39 p.m.)
Indexed	2 months, 2 weeks ago (June 4, 2025, 9:56 p.m.)
Issued	29 years, 10 months ago (Oct. 1, 1995)
Published	29 years, 10 months ago (Oct. 1, 1995)
Published Online	29 years, 10 months ago (Oct. 1, 1995)
Published Print	29 years, 10 months ago (Oct. 1, 1995)

Funders 0

None

BibTeX

@article{Carmena_1995, title={Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis.}, volume={9}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.9.19.2373}, DOI={10.1101/gad.9.19.2373}, number={19}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Carmena, A and Bate, M and Jiménez, F}, year={1995}, month=oct, pages={2373–2383} }

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