DOI: 10.1101/gad.855301. Requirement for <i>math5</i> in the development of retinal ganglion cells

Requirement for math5 in the development of retinal ganglion cells

10.1101/gad.855301

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression ofmath5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence ofmath5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b-expressing RGCs. These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activatebrn-3b-dependent differentiation processes in RGCs.

Bibliography

Wang, S. W., Kim, B. S., Ding, K., Wang, H., Sun, D., Johnson, R. L., Klein, W. H., & Gan, L. (2001). Requirement for math5 in the development of retinal ganglion cells. Genes & Development, 15(1), 24â29.

Authors 8

Steven W. Wang (first)
Byong Su Kim (additional)
Kan Ding (additional)
Huan Wang (additional)
Dantong Sun (additional)
Randy L. Johnson (additional)
William H. Klein (additional)
Lin Gan (additional)

References 29 Referenced 406

10.1242/dev.121.11.3637 / Development / Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. by Austin (1995)
10.1523/JNEUROSCI.17-04-01425.1997 / J. Neurosci. / The expression and function of Notch pathway genes in the developing rat eye. by Bao (1997)
10.1016/0306-4522(84)90195-7
10.1016/0006-8993(85)90806-6
10.1242/dev.126.3.555 / Development / Extrinsic and intrinsic factors control the genesis of amacrine and cone cells in the rat retina. by Belliveau (1999)
10.1523/JNEUROSCI.20-06-02247.2000 / J. Neurosci. / Late retinal progenitor cells show intrinsic limitations in the production of cell types and the kinetics of opsin synthesis. by Belliveau (2000)
10.1242/dev.125.23.4821 / Development / Math5 encodes a murine basic helix–loop–helix transcription factor expressed during early stages of retinal neurogenesis. by Brown (1998)
10.1016/0168-9525(92)90234-U
10.1016/S0959-4388(99)80005-1
10.1073/pnas.93.2.589
10.1016/0896-6273(95)90305-4
10.1242/dev.126.4.683 / Development / Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord. by Frade (1999)
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{'key': '2021111507315362000_15.1.24.15'}
10.1016/0092-8674(93)90525-U
10.1242/dev.121.7.2019 / Development / Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. by Jarman (1995)
10.1523/JNEUROSCI.18-21-08936.1998 / J. Neurosci. / The major cell populations of the mouse retina. by Jeon (1998)
10.1016/S0896-6273(00)80391-8
10.1242/dev.126.1.23 / Development / NeuroD regulates multiple functions in the developing neural retina in rodent. by Morrow (1999)
10.1016/0169-328X(89)90001-6
10.1016/0306-4522(81)90174-3
10.1016/0092-8674(93)90626-2
10.1111/j.1365-2443.1996.tb00016.x
10.1006/mcne.2000.0860
10.1152/physrev.1991.71.2.447 / Physiol. Rev. / Functional architecture of the mammalian retina. by Wassle (1991)
10.1242/dev.127.8.1681 / Development / Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling. by White (2000)
10.1002/ar.1092120215
{'key': '2021111507315362000_15.1.24.29', 'first-page': '229', 'article-title': 'Cell proliferation during postnatal development of the retina in the mouse.', 'volume': '353', 'year': '1985', 'journal-title': 'Brain Res.'} / Brain Res. / Cell proliferation during postnatal development of the retina in the mouse. (1985)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 8 p.m.)
Deposited	3 years, 9 months ago (Nov. 15, 2021, 10:34 a.m.)
Indexed	2 weeks ago (Aug. 19, 2025, 6:02 a.m.)
Issued	24 years, 8 months ago (Jan. 1, 2001)
Published	24 years, 8 months ago (Jan. 1, 2001)
Published Online	24 years, 8 months ago (Jan. 1, 2001)
Published Print	24 years, 8 months ago (Jan. 1, 2001)

Funders 0

None

BibTeX

@article{Wang_2001, title={Requirement for math5 in the development of retinal ganglion cells}, volume={15}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.855301}, DOI={10.1101/gad.855301}, number={1}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Wang, Steven W. and Kim, Byong Su and Ding, Kan and Wang, Huan and Sun, Dantong and Johnson, Randy L. and Klein, William H. and Gan, Lin}, year={2001}, month=jan, pages={24–29} }

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