DOI: 10.1101/gad.814700. A <i>C. elegans</i> mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene

A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene

10.1101/gad.814700

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The Caenorhabditis elegans caudal homolog, pal-1, is required for neurogenesis in the male tail. We show that expression ofpal-1 in the postembryonic neuroblast cell V6 can be initiated by two alternate pathways. One pathway, acting in wild type, requires a regulatory element in the fifth pal-1 intron. The other pathway, independent of this element, is normally repressed by the newly identified gene sop-1, which encodes a homolog of the mammalian Mediator complex protein TRAP230. In sop-1 mutants,pal-1 is activated by a pathway that is stimulated bybar-1/β-catenin, a component of the Wnt signal transduction pathway. The results support a physiological role of the Mediator complex in conveying regulatory signals to the transcriptional apparatus.

Bibliography

Zhang, H., & Emmons, S. W. (2000). A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene. Genes & Development, 14(17), 2161â2172.

Authors 2

Hong Zhang (first)
Scott W. Emmons (additional)

References 41 Referenced 71

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Dates

Type	When
Created	23 years ago (July 26, 2002, 8 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:36 p.m.)
Indexed	1 week, 2 days ago (Aug. 12, 2025, 5:47 p.m.)
Issued	24 years, 11 months ago (Sept. 1, 2000)
Published	24 years, 11 months ago (Sept. 1, 2000)
Published Online	24 years, 11 months ago (Sept. 1, 2000)
Published Print	24 years, 11 months ago (Sept. 1, 2000)

Funders 0

None

BibTeX

@article{Zhang_2000, title={A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene}, volume={14}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.814700}, DOI={10.1101/gad.814700}, number={17}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Zhang, Hong and Emmons, Scott W.}, year={2000}, month=sep, pages={2161–2172} }

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