DOI: 10.1101/gad.8.8.939. Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor.

Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor.

10.1101/gad.8.8.939

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

It has been shown previously that a Xenopus homolog of the mouse gene Brachyury, Xbra, can initiate mesodermal differentiation. Here, I report that a Xbra mutant truncated at the carboxyl terminus, B304, has lost the mesodermalizing activity and can block the activity of the wild-type Xbra. Injection of B304 mRNA led to formation of neural structures in animal cap explants. Examination of molecular markers in B304-injected explants shows expression of anterior neural markers in the absence of mesodermal markers, indicating that B304 can cause neuralization without the mediation of mesoderm. Implications of these findings on intracellular mechanisms underlying the initiation of neural differentiation in the ectodermal cells are discussed.

Bibliography

Rao, Y. (1994). Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor. Genes & Development, 8(8), 939â947.

Authors 1

Y Rao (first)

References 47 Referenced 46

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Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 9:20 p.m.)
Indexed	1 year, 1 month ago (Aug. 3, 2024, 5:46 p.m.)
Issued	31 years, 4 months ago (April 15, 1994)
Published	31 years, 4 months ago (April 15, 1994)
Published Online	31 years, 4 months ago (April 15, 1994)
Published Print	31 years, 4 months ago (April 15, 1994)

Funders 0

None

BibTeX

@article{Rao_1994, title={Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor.}, volume={8}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.8.8.939}, DOI={10.1101/gad.8.8.939}, number={8}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Rao, Y}, year={1994}, month=apr, pages={939–947} }

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