DOI: 10.1101/gad.8.7.757. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

10.1101/gad.8.7.757

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The bmi-1 proto-oncogene has been implicated in B-cell lymphomagenesis in E mu-myc transgenic mice. Distinct domains of the Bmi-1 protein are highly conserved within the Drosophila protein Posterior Sex Combs, a member of the Polycomb group involved in maintaining stable repression of homeotic genes during development. We have inactivated the bmi-1 gene in the germ line of mice by homologous recombination in ES cells. Null mutant mice display three phenotypic alterations: (1) a progressive decrease in the number of hematopoietic cells and an impaired proliferative response of these cells to mitogens; (2) neurological abnormalities manifested by an ataxic gait and sporadic seizures; and (3) posterior transformation, in most cases along the complete anteroposterior axis of the skeleton. The observations indicate that Mbi-1 plays an important role in morphogenesis during embryonic development and in hematopoiesis throughout pre- and postnatal life. Furthermore, these data provide the first evidence of functional conservation of a mammalian Polycomb group homolog.

Bibliography

van der Lugt, N. M., Domen, J., Linders, K., van Roon, M., Robanus-Maandag, E., te Riele, H., van der Valk, M., Deschamps, J., Sofroniew, M., & van Lohuizen, M. (1994). Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes & Development, 8(7), 757â769.

Authors 10

N M van der Lugt (first)
J Domen (additional)
K Linders (additional)
M van Roon (additional)
E Robanus-Maandag (additional)
H te Riele (additional)
M van der Valk (additional)
J Deschamps (additional)
M Sofroniew (additional)
M van Lohuizen (additional)

References 56 Referenced 642

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Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	2 years, 3 months ago (May 12, 2023, 2:25 a.m.)
Indexed	2 days, 7 hours ago (Aug. 20, 2025, 8:47 a.m.)
Issued	31 years, 4 months ago (April 1, 1994)
Published	31 years, 4 months ago (April 1, 1994)
Published Online	31 years, 4 months ago (April 1, 1994)
Published Print	31 years, 4 months ago (April 1, 1994)

Funders 0

None

BibTeX

@article{van_der_Lugt_1994, title={Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.}, volume={8}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.8.7.757}, DOI={10.1101/gad.8.7.757}, number={7}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={van der Lugt, N M and Domen, J and Linders, K and van Roon, M and Robanus-Maandag, E and te Riele, H and van der Valk, M and Deschamps, J and Sofroniew, M and van Lohuizen, M}, year={1994}, month=apr, pages={757–769} }

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