DOI: 10.1101/gad.8.15.1750. p21-containing cyclin kinases exist in both active and inactive states.

p21-containing cyclin kinases exist in both active and inactive states.

10.1101/gad.8.15.1750

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

In normal fibroblasts CDKs exist predominantly in p21/PCNA/cyclin/CDK quaternary complexes, whereas in p53-deficient cells, p21 expression is depressed and the kinases are reduced to a cyclin/CDK binary state. p21 is a universal cyclin kinase inhibitor, but we show here that p21-containing complexes exist in both catalytically active and inactive forms. This finding challenges the current view that active cyclin kinases function only in the binary state and reveals the subtlety with which tumor-suppressor proteins modulate the cell cycle.

Bibliography

Zhang, H., Hannon, G. J., & Beach, D. (1994). p21-containing cyclin kinases exist in both active and inactive states. Genes & Development, 8(15), 1750â1758.

Authors 3

H Zhang (first)
G J Hannon (additional)
D Beach (additional)

References 14 Referenced 477

10.1016/0968-0004(90)90235-4
10.1016/0092-8674(94)90379-4
10.1016/0092-8674(93)90500-P
10.1038/366707a0
10.1016/0003-2697(91)90534-Z
10.1101/gad.7.12a.2378 / Genes & Dev. / Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. (1993)
10.1016/0092-8674(93)90499-G
10.1073/pnas.82.2.488
{'key': '2021111418164182000_8.15.1750.9', 'first-page': '2066', 'article-title': 'D-type cyclin-dependent kinase activity in mammalian cells.', 'volume': '14', 'year': '1994', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / D-type cyclin-dependent kinase activity in mammalian cells. (1994)
10.1016/0092-8674(93)90636-5 / Cell / Mammalian G1 cyclins. (1993)
10.1016/0092-8674(92)90518-H
10.1101/gad.7.8.1572
10.1038/366701a0
10.1091/mbc.4.9.897

Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 9:23 p.m.)
Indexed	3 weeks, 3 days ago (July 30, 2025, 11:10 a.m.)
Issued	31 years ago (Aug. 1, 1994)
Published	31 years ago (Aug. 1, 1994)
Published Online	31 years ago (Aug. 1, 1994)
Published Print	31 years ago (Aug. 1, 1994)

Funders 0

None

BibTeX

@article{Zhang_1994, title={p21-containing cyclin kinases exist in both active and inactive states.}, volume={8}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.8.15.1750}, DOI={10.1101/gad.8.15.1750}, number={15}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Zhang, H and Hannon, G J and Beach, D}, year={1994}, month=aug, pages={1750–1758} }

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