Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae.
10.1101/gad.8.12.1411
Crossref journal-article
Cold Spring Harbor Laboratory
Genes & Development (246)
Abstract

Telomeric position effect (TPE) refers to the ability of telomeres to repress the transcription of genes in their vicinity. Internal stretches of C1-3A DNA, the sequence found at Saccharomyces telomeres, also repressed transcription of nearby genes. This repression, hereafter called C1-3A-based silencing, was observed at several chromosomal loci, including on a circular chromosome. The magnitude of C1-3A-based silencing was increased by both proximity to a telomere and increased length of the C1-3A tracts. C1-3A-based silencing was affected by many of the same genes and conditions that influence TPE and acted in an orientation-independent manner. Thus, in yeast, an expanded array of a simple repetitive DNA, C1-3A, is sufficient to promote the assembly of a transcriptionally silent chromosomal domain.

Bibliography

Stavenhagen, J. B., & Zakian, V. A. (1994). Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae. Genes & Development, 8(12), 1411–1422.

Authors 2
  1. J B Stavenhagen (first)
  2. V A Zakian (additional)
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Dates
Type When
Created 18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited 3 years, 9 months ago (Nov. 14, 2021, 9:22 p.m.)
Indexed 4 weeks, 1 day ago (Aug. 6, 2025, 7:59 a.m.)
Issued 31 years, 2 months ago (June 15, 1994)
Published 31 years, 2 months ago (June 15, 1994)
Published Online 31 years, 2 months ago (June 15, 1994)
Published Print 31 years, 2 months ago (June 15, 1994)
Funders 0

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@article{Stavenhagen_1994, title={Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae.}, volume={8}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.8.12.1411}, DOI={10.1101/gad.8.12.1411}, number={12}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Stavenhagen, J B and Zakian, V A}, year={1994}, month=jun, pages={1411–1422} }