Specific regulation of Xenopus chromosomal 5S rRNA gene transcription in vivo by histone H1.
10.1101/gad.8.10.1147
Crossref journal-article
Cold Spring Harbor Laboratory
Genes & Development (246)
Abstract

The incorporation of histone H1 into chromatin during embryogenesis directs the specific repression of the Xenopus oocyte 5S rRNA genes. An increase in histone H1 content specifically restricts TFIIIA-activated transcription, and a decrease in histone H1 within chromatin facilitates the activation of the oocyte 5S rRNA genes by TFIIIA. Variation in the amount of histone H1 in chromatin does not significantly influence somatic 5S rRNA gene transcription. Thus, the regulated expression of histone H1 during Xenopus development has a specific and dominant role in mediating the differential expression of the oocyte and somatic 5S rRNA genes. This example demonstrates that histones can exert dominant repressive effects on the transcription of a gene in vivo in spite of an abundance of transcription factors for that gene.

Bibliography

Bouvet, P., Dimitrov, S., & Wolffe, A. P. (1994). Specific regulation of Xenopus chromosomal 5S rRNA gene transcription in vivo by histone H1. Genes & Development, 8(10), 1147–1159.

Authors 3
  1. P Bouvet (first)
  2. S Dimitrov (additional)
  3. A P Wolffe (additional)
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Dates
Type When
Created 18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited 3 years, 9 months ago (Nov. 14, 2021, 9:20 p.m.)
Indexed 2 weeks, 5 days ago (Aug. 7, 2025, 4:56 a.m.)
Issued 31 years, 3 months ago (May 15, 1994)
Published 31 years, 3 months ago (May 15, 1994)
Published Online 31 years, 3 months ago (May 15, 1994)
Published Print 31 years, 3 months ago (May 15, 1994)
Funders 0

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@article{Bouvet_1994, title={Specific regulation of Xenopus chromosomal 5S rRNA gene transcription in vivo by histone H1.}, volume={8}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.8.10.1147}, DOI={10.1101/gad.8.10.1147}, number={10}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Bouvet, P and Dimitrov, S and Wolffe, A P}, year={1994}, month=may, pages={1147–1159} }