DOI: 10.1101/gad.7.5.812. Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

10.1101/gad.7.5.812

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

A cascade of events is triggered upon the addition of growth factor to quiescent mammalian cells, which ultimately restarts proliferation by inducing the transition from G0/G1 to S-phase. We have studied cyclin D1, a putative G1 cyclin, in normal diploid human fibroblasts. Cyclin D1 accumulated and reached a maximum level before S-phase upon the addition of serum to quiescent cells. The protein was localized to the nucleus, and it disappeared from the nucleus as cells proceeded into S-phase. Microinjection of anti-cyclin D1 antibodies or antisense plasmid prevented cells from entering S-phase, and the kinetics of inhibition showed that cyclin D1 is required at a point in the cell cycle earlier than cyclin A. These results demonstrate that cyclin D1 is a critical target of proliferative signals in G1.

Bibliography

Baldin, V., Lukas, J., Marcote, M. J., Pagano, M., & Draetta, G. (1993). Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes & Development, 7(5), 812â821.

Authors 5

V Baldin (first)
J Lukas (additional)
M J Marcote (additional)
M Pagano (additional)
G Draetta (additional)

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Dates

Type	When
Created	18 years, 3 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 9:09 p.m.)
Indexed	1 week, 1 day ago (Aug. 28, 2025, 8:37 a.m.)
Issued	32 years, 4 months ago (May 1, 1993)
Published	32 years, 4 months ago (May 1, 1993)
Published Online	32 years, 4 months ago (May 1, 1993)
Published Print	32 years, 4 months ago (May 1, 1993)

Funders 0

None

BibTeX

@article{Baldin_1993, title={Cyclin D1 is a nuclear protein required for cell cycle progression in G1.}, volume={7}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.7.5.812}, DOI={10.1101/gad.7.5.812}, number={5}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Baldin, V and Lukas, J and Marcote, M J and Pagano, M and Draetta, G}, year={1993}, month=may, pages={812–821} }

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