DOI: 10.1101/gad.7.10.1862. The carboxy-terminal tail of the homeo domain protein alpha 2 is required for function with a second homeo domain protein.

The carboxy-terminal tail of the homeo domain protein alpha 2 is required for function with a second homeo domain protein.

10.1101/gad.7.10.1862

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The homeo domain protein alpha 2 from Saccharomyces cerevisiae has two roles in the a/alpha cell: With MCM1, alpha 2 turns off transcription of a-specific genes; with a1 (a second homeo domain protein), alpha 2 represses transcription of haploid-specific genes. From the carboxy-terminal side of the alpha 2 homeo domain extends an unstructured 22-amino-acid residue tail. In this paper we show that the carboxy-terminal tail of alpha 2 is required for formation of a stable a1/alpha 2-operator complex and is thus required for a1/alpha 2-mediated repression of transcription. In contrast, the tail is dispensable for alpha 2/MCM1-mediated repression. These results indicate that a short, unstructured tail mediates the interaction between two homeo domain proteins.

Bibliography

Mak, A., & Johnson, A. D. (1993). The carboxy-terminal tail of the homeo domain protein alpha 2 is required for function with a second homeo domain protein. Genes & Development, 7(10), 1862â1870.

Authors 2

A Mak (first)
A D Johnson (additional)

References 43 Referenced 53

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{'key': '2021111418104896000_7.10.1862.3', 'first-page': '11', 'article-title': 'Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and α factor pheromones.', 'volume': '2', 'year': '1982', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and α factor pheromones. (1982)
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{'key': '2021111418104896000_7.10.1862.8', 'first-page': '551', 'article-title': 'Yeast STE7, STE11, and STE12 genes are required for expression of cell-type-specific genes.', 'volume': '8', 'year': '1988', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / Yeast STE7, STE11, and STE12 genes are required for expression of cell-type-specific genes. (1988)
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Goutte, C. and A.D. Johnson. 1993. The yeast al and α2 homeo domain proteins form a DNA binding activity with properties distinct from those of either protein. J. Mol. Biol. (in press). (10.1006/jmbi.1993.1517)
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{'key': '2021111418104896000_7.10.1862.14', 'first-page': '4523', 'article-title': 'Mating-type control in Saccharomyces cerevisiae: Isolation and characterization of mutants defective in repression by a1-α2.', 'volume': '9', 'year': '1989', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / Mating-type control in Saccharomyces cerevisiae: Isolation and characterization of mutants defective in repression by a1-α2. (1989)
10.1038/342749a0
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{'key': '2021111418104896000_7.10.1862.36', 'first-page': '33', 'article-title': 'Combinatorial associations of regulatory proteins and the control of cell type in yeast.', 'volume': '17', 'year': '1990', 'journal-title': 'Adv. Genet.'} / Adv. Genet. / Combinatorial associations of regulatory proteins and the control of cell type in yeast. (1990)
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{'key': '2021111418104896000_7.10.1862.41', 'first-page': '1', 'article-title': 'A short, disordered protein region mediates interactions between the homeo domain of the yeast α2 protein and the Mcm1 protein.', 'volume': '72', 'year': '1993', 'journal-title': 'Cell'} / Cell / A short, disordered protein region mediates interactions between the homeo domain of the yeast α2 protein and the Mcm1 protein. (1993)
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Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 9:14 p.m.)
Indexed	1 year, 7 months ago (Jan. 12, 2024, 4:41 p.m.)
Issued	31 years, 10 months ago (Oct. 1, 1993)
Published	31 years, 10 months ago (Oct. 1, 1993)
Published Online	31 years, 10 months ago (Oct. 1, 1993)
Published Print	31 years, 10 months ago (Oct. 1, 1993)

Funders 0

None

BibTeX

@article{Mak_1993, title={The carboxy-terminal tail of the homeo domain protein alpha 2 is required for function with a second homeo domain protein.}, volume={7}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.7.10.1862}, DOI={10.1101/gad.7.10.1862}, number={10}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Mak, A and Johnson, A D}, year={1993}, month=oct, pages={1862–1870} }

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