A novel modulator domain of Ets transcription factors.
10.1101/gad.6.6.965
Crossref journal-article
Cold Spring Harbor Laboratory
Genes & Development (246)
Abstract

The ets gene family is composed of several oncogenes and codes for transcription factors. The Ets proteins have a similar sequence called the ets domain and bind to the core motif A/CGGAA. We show here that several members of the ets family have different trans-activating properties. The ets domain of Ets-1 is required for DNA binding. Adjacent to this domain there is a novel element that inhibits DNA binding. It appears to alter the structure of the DNA-binding domain before it interacts with DNA. There is a similar sequence in Ets-2 that also inhibits DNA binding. This sequence is absent in alternative splice products of h-Ets-1. PU1, the most distantly related member of the ets gene family, lacks this novel element. It has a distinct DNA-binding specificity that is determined by DNA sequences outside the core motif. These results have important implications for both the oncogenic and normal functions of ets family members.

Bibliography

Wasylyk, C., Kerckaert, J. P., & Wasylyk, B. (1992). A novel modulator domain of Ets transcription factors. Genes & Development, 6(6), 965–974.

Authors 3
  1. C Wasylyk (first)
  2. J P Kerckaert (additional)
  3. B Wasylyk (additional)
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Dates
Type When
Created 18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited 2 years, 3 months ago (May 12, 2023, 2:26 a.m.)
Indexed 1 month, 4 weeks ago (July 5, 2025, 1:21 a.m.)
Issued 33 years, 3 months ago (June 1, 1992)
Published 33 years, 3 months ago (June 1, 1992)
Published Online 33 years, 3 months ago (June 1, 1992)
Published Print 33 years, 3 months ago (June 1, 1992)
Funders 0

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@article{Wasylyk_1992, title={A novel modulator domain of Ets transcription factors.}, volume={6}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.6.6.965}, DOI={10.1101/gad.6.6.965}, number={6}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Wasylyk, C and Kerckaert, J P and Wasylyk, B}, year={1992}, month=jun, pages={965–974} }