DOI: 10.1101/gad.6.6.1030. The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors.

The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors.

10.1101/gad.6.6.1030

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The sloppy paired locus is involved in the establishment of the metameric body plan of the Drosophila embryo. We have cloned the sloppy paired locus by P-element-mediated enhancer detection. The locus is composed of two genes, slp1 and slp2, that are structurally and functionally related. They belong to a novel class of putative transcription factors containing a fork head domain that has also been found in mammalian hepatocyte transcription factors. The spatial expression patterns of the two transcripts are very similar, suggesting common regulation of the two genes. We recovered additional sloppy paired alleles by remobilization of an enhancer detector transposon. Genetic analysis suggests that both genes contribute to the segmentation phenotype that has characteristics of both, pair-rule and segment polarity genes, and that they interact functionally. The two genes appear to share an enhancer element situated upstream of slp1 that acts on both the proximal slp1 promoter and the distal slp2 promoter.

Authors 3

U Grossniklaus (first)
R K Pearson (additional)
W J Gehring (additional)

References 78 Referenced 188

10.1016/0955-0674(90)90132-X
10.1038/msb.2012.72
10.1101/gad.1.10.1247
10.1002/j.1460-2075.1987.tb02429.x / EMBO J. / Molecular cloning of wingless, a segment polarity gene in Drosophila. The spatial distribution of a transcript in embryos. (1987)
10.1101/gad.3.9.1288
10.1007/BF00425856
Campos-Ortega, J.A. and V. Hartenstein. 1985. The embryonic development of Drosophila melanogaster. Springer-Verlag, Berlin. (10.1007/978-3-662-02454-6)
10.1093/nar/15.4.1353
10.1038/346482a0
10.1101/gad.1.1.19 / Genes & Dev. / The invected gene of Drosophila: Sequence analysis and expression studies reveal a close kinship to the engrailed gene. (1987)
10.1002/j.1460-2075.1987.tb02575.x / EMBO J. / The gooseberry-zipper region of Drosophila: Five genes encode different spatially restricted transcripts in the embryo. (1987)
10.1101/gad.2.12b.1812
{'key': '2021111320224974000_6.6.1030.13', 'first-page': '3795', 'article-title': 'Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern.', 'volume': '8', 'year': '1990', 'journal-title': 'EMBO J.'} / EMBO J. / Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern. (1990)
10.1093/nar/12.1Part1.387
10.1101/gad.1.10.1212
10.1016/0092-8674(85)90012-1
10.1101/gad.3.10.1518
10.1242/dev.111.2.367 / Development / Interactions of the Drosophila gap gene giant with maternal and zygotic pattern forming genes. (1991)
10.1016/0092-8674(91)90209-H
10.1038/346485a0
10.1038/313284a0
10.1093/nar/15.24.10159
10.1002/j.1460-2075.1987.tb04817.x / EMBO J. / Characterization and localization of the even-skipped protein of Drosophila. (1987)
10.1073/pnas.82.5.1396
10.1101/gad.2.9.1179
10.1242/dev.107.2.189 / Development / P-element-mediated enhancer detection applied to the study of oogenesis in Drosophila. (1989)
10.1016/0092-8674(87)90584-8
10.1016/0092-8674(84)90418-5
10.1101/gad.5.8.1387
10.1126/science.3755551
10.1016/0092-8674(90)90492-W
10.1093/nar/16.8.3175
10.1016/0022-2836(83)90046-3
10.1038/335025a0
10.1016/S0959-437X(05)80080-2
10.1038/318439a0
10.1007/BF00402870
10.1101/gad.4.3.433
10.1093/genetics/94.1.115 / Genetics / Cytogenetic analysis of chromosome 3 in Drosophila melanogaster: The homeotic gene complex in polytene chromosome interval 84A-B. (1980)
10.1038/321493a0
10.1038/317040a0
10.1073/pnas.78.2.1095
10.1016/0092-8674(85)90307-1
10.1101/gad.2.8.1021
10.1242/dev.111.2.601 / Development / Spatial regulation of the gap gene giant during Drosophila development. (1991)
10.1101/gad.4.8.1427
10.1101/gad.5.3.416
10.1038/328440a0
10.1038/276565a0
Lindsley, D.L. and Zimm. G. 1990. The genome of Drosophila melanogaster. Part 4: Genes L–Z, balancers, transposable elements. Drosophila Info. Serv. 68.
10.1016/0092-8674(86)90515-5
10.1016/0092-8674(78)90036-3
10.1016/0092-8674(84)90370-2
10.1038/287795a0
10.1007/BF00848156
10.1101/SQB.1985.050.01.020 / Cold Spring Harbor Symp. Quant. Biol. / Genes affecting the segmental subdivision of the Drosophila embryo. (1985)
10.1242/dev.110.1.141 / Development / The closely related Drosophila sryβ and sryδ zinc finger proteins show differential embryonic expression and distinct patterns of binding sites on polytene chromosomes. (1990)
10.1073/pnas.85.8.2444
10.1016/0092-8674(85)90306-X
10.1038/263211a0
10.1101/gad.2.7.901
10.1007/BF00292904
10.1093/genetics/118.3.461 / Genetics / A stable source of P-element transposase in Drosophila melanogaster. (1988)
10.1038/319336a0
10.1101/gad.1.10.1268
10.1126/science.2999980
Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
10.1073/pnas.81.13.4115
10.1007/BF00291041
10.1038/327383a0
{'key': '2021111320224974000_6.6.1030.71', 'first-page': '209', 'article-title': 'Tübingen mutants and stocklist.', 'volume': '66', 'year': '1987', 'journal-title': 'Drosophila Info. Serv.'} / Drosophila Info. Serv. / Tübingen mutants and stocklist. (1987)
{'key': '2021111320224974000_6.6.1030.72', 'first-page': '96', 'article-title': 'Scanning electron microscopy of Drosophila melanogaster embryogenesis. III. Formation of the head and caudal segments.', 'volume': '86', 'year': '1979', 'journal-title': 'Dev. Biol.'} / Dev. Biol. / Scanning electron microscopy of Drosophila melanogaster embryogenesis. III. Formation of the head and caudal segments. (1979)
10.1016/0022-2836(85)90265-7
10.1016/0012-1606(84)90182-9
10.1016/0092-8674(90)90439-L
10.1016/0092-8674(89)90133-5
10.1007/BF00329666
10.1101/gad.3.9.1301

Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 13, 2021, 11:25 p.m.)
Indexed	1 week, 1 day ago (Aug. 19, 2025, 6:06 a.m.)
Issued	33 years, 2 months ago (June 1, 1992)
Published	33 years, 2 months ago (June 1, 1992)
Published Online	33 years, 2 months ago (June 1, 1992)
Published Print	33 years, 2 months ago (June 1, 1992)

Funders 0

None

BibTeX

@article{Grossniklaus_1992, title={The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors.}, volume={6}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.6.6.1030}, DOI={10.1101/gad.6.6.1030}, number={6}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Grossniklaus, U and Pearson, R K and Gehring, W J}, year={1992}, month=jun, pages={1030–1051} }

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