DOI: 10.1101/gad.6.4.599. A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain.

A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain.

10.1101/gad.6.4.599

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The organizer region, or dorsal blastopore lip, plays a central role in the initiation of gastrulation and the formation of the body axis during Xenopus development. A similar process can also be induced in ectodermal explants by activin or by injection of activin mRNA into embryos. We have searched early embryo-specific cDNA libraries for genes containing the fork head box sequence that encodes a DNA-binding domain similar to that of the Drosophila homeotic gene fork head and rat hepatocyte nuclear factor HFN3 beta. These genes were subsequently tested for expression in the organizer region of blastula/gastrula-stage embryos as well as inducibility by activin. Our effort resulted in the isolation of a gene, XFKH1, that is primarily expressed in the dorsal blastopore lip of early gastrulae and is inducible by activin. At later stages it is expressed in the notochord and neural floor plate. Because of its spatial and temporal expression pattern, as well as its inducibility by activin, this gene is a good candidate to have a regulatory function in the initial processes of axis formation in Xenopus laevis embryos.

Bibliography

Dirksen, M. L., & Jamrich, M. (1992). A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain. Genes & Development, 6(4), 599â608.

Authors 2

M L Dirksen (first)
M Jamrich (additional)

References 58 Referenced 184

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{'key': '2021111320220468000_6.4.599.15', 'first-page': '37', 'article-title': 'Cortical rotation of Xenopus egg: Consequences for the anteroposterior pattern of embryonic dorsal development.', 'volume': '107', 'year': '1989', 'journal-title': 'Development (Suppl.)'} / Development (Suppl.) / Cortical rotation of Xenopus egg: Consequences for the anteroposterior pattern of embryonic dorsal development. (1989)
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{'key': '2021111320220468000_6.4.599.52', 'first-page': '599', 'article-title': 'Ueber Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren.', 'volume': '100', 'year': '1924', 'journal-title': "Wilhelm Roux's Arch. Entwicklungsmech. Org."} / Wilhelm Roux's Arch. Entwicklungsmech. Org. / Ueber Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren. (1924)
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Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 13, 2021, 11:25 p.m.)
Indexed	1 month ago (July 27, 2025, 3:44 a.m.)
Issued	33 years, 4 months ago (April 1, 1992)
Published	33 years, 4 months ago (April 1, 1992)
Published Online	33 years, 4 months ago (April 1, 1992)
Published Print	33 years, 4 months ago (April 1, 1992)

Funders 0

None

BibTeX

@article{Dirksen_1992, title={A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain.}, volume={6}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.6.4.599}, DOI={10.1101/gad.6.4.599}, number={4}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Dirksen, M L and Jamrich, M}, year={1992}, month=apr, pages={599–608} }

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