LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]
10.1101/gad.5.5.880
Crossref journal-article
Cold Spring Harbor Laboratory
Genes & Development (246)
Abstract

Lymphoid-specific cDNA clones were isolated that encode a nuclear protein with homology to the chromosomal nonhistone protein HMG-1 and to putative regulators of cell specialization, including the mammalian testis-determining factor SRY and fungal mating-type proteins. The gene represented by the isolated cDNA clones, termed LEF-1 (lymphoid enhancer-binding factor 1), is developmentally regulated and expressed in pre-B and T lymphocytes but not in later-stage B cells or nonlymphoid tissues. Both endogenous and recombinant LEF-1 were shown to bind to a functionally important site in the T-cell antigen receptor (TCR) alpha enhancer. Maximal TCR alpha enhancer activity was found to parallel the cell type-specific expression pattern of LEF-1. Moreover, forced expression of recombinant LEF-1 in late stage B cells increases TCR alpha enhancer function. Taken together, these data suggest that LEF-1 is a regulatory participant in lymphocyte gene expression and differentiation.

Bibliography

Travis, A., Amsterdam, A., Belanger, C., & Grosschedl, R. (1991). LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]. Genes & Development, 5(5), 880–894.

Authors 4
  1. A Travis (first)
  2. A Amsterdam (additional)
  3. C Belanger (additional)
  4. R Grosschedl (additional)
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Dates
Type When
Created 18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited 2 years, 3 months ago (May 12, 2023, 2:21 a.m.)
Indexed 1 month, 1 week ago (July 12, 2025, 6:52 p.m.)
Issued 34 years, 3 months ago (May 1, 1991)
Published 34 years, 3 months ago (May 1, 1991)
Published Online 34 years, 3 months ago (May 1, 1991)
Published Print 34 years, 3 months ago (May 1, 1991)
Funders 0

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@article{Travis_1991, title={LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]}, volume={5}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.5.5.880}, DOI={10.1101/gad.5.5.880}, number={5}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Travis, A and Amsterdam, A and Belanger, C and Grosschedl, R}, year={1991}, month=may, pages={880–894} }