DOI: 10.1101/gad.5.3.456. Forespore-specific transcription of a gene in the signal transduction pathway that governs Pro-sigma K processing in Bacillus subtilis.

Forespore-specific transcription of a gene in the signal transduction pathway that governs Pro-sigma K processing in Bacillus subtilis.

10.1101/gad.5.3.456

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

We present studies on the regulation of a developmental gene (spoIVB) whose product is required at a late stage of morphogenesis during the process of sporulation in Bacillus subtilis. Earlier work implicated the spoIVB gene product in a signal-transduction pathway that governs the conversion of pro-sigma K to the mature and active form of the mother cell sigma factor, sigma K, in response to a signal generated within the forespore chamber of the sporangium. We now show that (1) spoIVB is induced at the engulfment stage of sporulation, (2) this transcription is restricted to the forespore, and (3) spoIVB is under the direct control of the forespore sigma factor sigma G. The discovery that spoIVB is a forespore-expressed gene suggests that the spoIVB gene product, or a developmental event under its control, triggers the processing of pro-sigma K and thereby mediates the coupling of sigma K-directed gene expression in the mother cell to sigma G-directed gene expression in the forespore. We also show that spoIVB transcription is partially dependent on the action of the mother cell regulatory gene spoIIID, a finding that suggests that the transcription of certain forespore-expressed genes is influenced by events in the mother cell.

Bibliography

Cutting, S., Driks, A., Schmidt, R., Kunkel, B., & Losick, R. (1991). Forespore-specific transcription of a gene in the signal transduction pathway that governs Pro-sigma K processing in Bacillus subtilis. Genes & Development, 5(3), 456â466.

Authors 5

S Cutting (first)
A Driks (additional)
R Schmidt (additional)
B Kunkel (additional)
R Losick (additional)

References 41 Referenced 130

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Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 13, 2021, 11:17 p.m.)
Indexed	1 month ago (July 24, 2025, 8:18 a.m.)
Issued	34 years, 5 months ago (March 1, 1991)
Published	34 years, 5 months ago (March 1, 1991)
Published Online	34 years, 5 months ago (March 1, 1991)
Published Print	34 years, 5 months ago (March 1, 1991)

Funders 0

None

BibTeX

@article{Cutting_1991, title={Forespore-specific transcription of a gene in the signal transduction pathway that governs Pro-sigma K processing in Bacillus subtilis.}, volume={5}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.5.3.456}, DOI={10.1101/gad.5.3.456}, number={3}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Cutting, S and Driks, A and Schmidt, R and Kunkel, B and Losick, R}, year={1991}, month=mar, pages={456–466} }

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