DOI: 10.1101/gad.5.3.416. Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

10.1101/gad.5.3.416

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

By analysis of cDNA clones that cross-hybridized with a portion of the cDNA encoding the recently described rat protein hepatocyte nuclear factor 3 alpha (HNF-3 alpha, previously called HNF-3A), we now describe two additional members, HNF-3 beta and HNF-3 gamma, of this gene family. A 110-amino-acid region in the DNA-binding domain of this family is not only very highly conserved in rodents (HNF-3 alpha, -3 beta, and -3 gamma are identical in 93 of 110 amino acids in this region) but also in Drosophila where the homeotic gene fork head has 88 of the 93 residues that are identical in the three rat genes. The HNF-3 family in rodents is expressed in cells that derive from the lining of the primitive gut; some of the embryonic Drosophila cells in which fork head is expressed also give rise to gut and salivary glands. Thus, it appears that this gene family, the DNA-binding portion of which is unlike that of any previously recognized DNA-binding proteins, may contribute to differentiation of cells in internal organs in both vertebrates and invertebrates.

Bibliography

Lai, E., Prezioso, V. R., Tao, W. F., Chen, W. S., & Darnell, J. E. (1991). Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes & Development, 5(3), 416â427.

Authors 5

E Lai (first)
V R Prezioso (additional)
W F Tao (additional)
W S Chen (additional)
J E Darnell (additional)

References 36 Referenced 381

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10.1101/gad.4.3.372
10.1016/0092-8674(87)90496-X
10.1016/0092-8674(88)90250-4
10.1038/328820a0
10.1016/0003-2697(87)90021-2
10.1128/MCB.6.12.4697
{'key': '2021111320164639000_5.3.416.8', 'first-page': '1415', 'article-title': 'Multiple hepatocyte-specfic nuclear factors function in the regulation of the transthyretin and al-antitrypsin genes.', 'volume': '9', 'year': '1989', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / Multiple hepatocyte-specfic nuclear factors function in the regulation of the transthyretin and al-antitrypsin genes. (1989)
10.1073/pnas.87.17.6589
10.1016/0092-8674(89)90877-5
{'key': '2021111320164639000_5.3.416.11', 'first-page': '1235', 'article-title': 'Homeo boxes in the study of development.', 'volume': '236', 'year': '1987', 'journal-title': 'Science'} / Science / Homeo boxes in the study of development. (1987)
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10.1242/dev.109.2.473 / Development / Fetal and adult localization of C/EBP: Evidence for combinatorial action of transcription factors in cell-specific gene expression. (1990)
10.1101/gad.4.8.1427
Lew, D.J., Decker, T. Strehlow, I. and Darnell. J.E. 1991. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol. Cell. Biol. 11: (in press). (10.1128/mcb.11.1.182-191.1991)
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{'key': '2021111320164639000_5.3.416.27', 'first-page': '148', 'article-title': 'An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.', 'volume': '8', 'year': '1990', 'journal-title': 'BioTechniques'} / BioTechniques / An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. (1990)
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10.1073/pnas.76.3.1373
{'key': '2021111320164639000_5.3.416.36', 'first-page': '4111', 'article-title': 'Cell-specific transcriptional control of the mouse DNA-binding protein C/EBP.', 'volume': '86', 'year': '1989', 'journal-title': 'Proc. Natl. Acad. Sci.'} / Proc. Natl. Acad. Sci. / Cell-specific transcriptional control of the mouse DNA-binding protein C/EBP. (1989)

Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 13, 2021, 11:17 p.m.)
Indexed	1 month, 3 weeks ago (July 2, 2025, 1:53 p.m.)
Issued	34 years, 5 months ago (March 1, 1991)
Published	34 years, 5 months ago (March 1, 1991)
Published Online	34 years, 5 months ago (March 1, 1991)
Published Print	34 years, 5 months ago (March 1, 1991)

Funders 0

None

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