DOI: 10.1101/gad.5.11.1935. Transcription from a TATA-less promoter requires a multisubunit TFIID complex.

Transcription from a TATA-less promoter requires a multisubunit TFIID complex.

10.1101/gad.5.11.1935

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

In eukaryotes, the TATA box-binding protein (TBP) is responsible for nucleating assembly of the transcription initiation machinery. Here, we report that a TFIID complex containing TBP is essential for transcription even at a promoter that lacks a TATA box. Immunopurification of TFIID reveals that the active species in reconstituting TATA-less transcription is a multisubunit complex consisting of TBP and many TBP-associated factors (TAFs).

Bibliography

Pugh, B. F., & Tjian, R. (1991). Transcription from a TATA-less promoter requires a multisubunit TFIID complex. Genes & Development, 5(11), 1935â1945.

Authors 2

B F Pugh (first)
R Tjian (additional)

References 40 Referenced 444

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{'key': '2021111320200924000_5.11.1935.25', 'first-page': '424', 'article-title': 'Participation of the TATA factor in transcription of the yeast U6 gene by RNA polymerase C.', 'volume': '251', 'year': '1991', 'journal-title': 'Nature'} / Nature / Participation of the TATA factor in transcription of the yeast U6 gene by RNA polymerase C. (1991)
10.1016/0092-8674(87)90512-5
10.1073/pnas.87.23.9148
{'key': '2021111320200924000_5.11.1935.28', 'first-page': '4028', 'article-title': 'Factors involved in specific transcription by mammalian RNA polymerase II: Purification, genetic specificity, and TATA box-promoter interactions of TFIID.', 'volume': '8', 'year': '1988', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / Factors involved in specific transcription by mammalian RNA polymerase II: Purification, genetic specificity, and TATA box-promoter interactions of TFIID. (1988)
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10.1096/fasebj.3.6.2649403 / FASEB J. / Promoter specificity and modulation of RNA polymerase II transcription. (1989)
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Tanese, N., Pugh, B.F. and Tjian. R. 1991. Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex. Genes & Dev. (in press). (10.1101/gad.5.12a.2212)
10.1016/S0021-9258(18)60493-4 / J. Biol. Chem. / Inhibition of in vivo and in vitro transcription by monoclonal antibodies prepared against wheat germ RNA polymerase II that react with the heptapeptide repeat of eukaryotic RNA polymerase II. (1989)
10.1016/0092-8674(91)90237-S

Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 13, 2021, 11:22 p.m.)
Indexed	2 weeks, 1 day ago (Aug. 7, 2025, 4:44 p.m.)
Issued	33 years, 9 months ago (Nov. 1, 1991)
Published	33 years, 9 months ago (Nov. 1, 1991)
Published Online	33 years, 9 months ago (Nov. 1, 1991)
Published Print	33 years, 9 months ago (Nov. 1, 1991)

Funders 0

None

BibTeX

@article{Pugh_1991, title={Transcription from a TATA-less promoter requires a multisubunit TFIID complex.}, volume={5}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.5.11.1935}, DOI={10.1101/gad.5.11.1935}, number={11}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Pugh, B F and Tjian, R}, year={1991}, month=nov, pages={1935–1945} }

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