DOI: 10.1101/gad.4.8.1267. A homeo domain protein reveals the metameric nature of the developing chick hindbrain.

A homeo domain protein reveals the metameric nature of the developing chick hindbrain.

10.1101/gad.4.8.1267

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The segmented embryonic hindbrain of vertebrates develops by sequential constriction of the neural tube into eight metameric units known as rhombomeres. The cellular and molecular basis of this segmentation process is largely unknown. Using an antibody, we analyzed the expression pattern of the chick homeo domain-containing protein Ghox-lab in the developing chick hindbrain. At the neural plate stage, prior to the appearance of rhombomeres, Ghox-lab is expressed within a single domain that extends anteriorly up to the site where rhombomere 4 will later form. After rhombomere 4 has appeared and as hindbrain segmentation progresses, the level of Ghox-lab protein increases significantly within the fourth rhombomere. This intensification, accompanied by the elimination of Ghox-lab protein in rhombomeres 5 and 6, eventually results in the formation of a distinct island of expression in rhombomere 4. All cells in the newly formed rhombomere 4 express Ghox-lab, except for the cells of the floor plate. In addition, neural crest cells migrating from the fourth rhombomere are also Ghox-lab-positive. These data raise the possibility that Ghox-lab protein might be one of the factors involved in the specification of the metameric pattern of the vertebrate hindbrain.

Bibliography

Sundin, O. H., & Eichele, G. (1990). A homeo domain protein reveals the metameric nature of the developing chick hindbrain. Genes & Development, 4(8), 1267â1276.

Authors 2

O H Sundin (first)
G Eichele (additional)

References 48 Referenced 98

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Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 13, 2021, 11:10 p.m.)
Indexed	1 year, 1 month ago (July 10, 2024, 11:21 a.m.)
Issued	35 years ago (Aug. 1, 1990)
Published	35 years ago (Aug. 1, 1990)
Published Online	35 years ago (Aug. 1, 1990)
Published Print	35 years ago (Aug. 1, 1990)

Funders 0

None

BibTeX

@article{Sundin_1990, title={A homeo domain protein reveals the metameric nature of the developing chick hindbrain.}, volume={4}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.4.8.1267}, DOI={10.1101/gad.4.8.1267}, number={8}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Sundin, O H and Eichele, G}, year={1990}, month=aug, pages={1267–1276} }

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