The secE gene encodes an integral membrane protein required for protein export in Escherichia coli.
10.1101/gad.3.7.1035
Crossref journal-article
Cold Spring Harbor Laboratory
Genes & Development (246)
Abstract

Genetic screening and selection procedures employing a secA-lacZ fusion strain repeatedly have yielded mutations in four genes affecting the protein export pathway of Escherichia coli. These genes are secA, secD, prlA/secY, and secE. We discuss the significance of the failure to find new sec genes after extensive use of this approach. One of the genes, secE, has been characterized in some detail. From the DNA sequence of the gene and analysis of alkaline phosphatase fusions to the SecE protein, we propose that it is a 13,600-dalton integral cytoplasmic membrane protein. The data presented here and in the accompanying paper strongly suggest that secE has an important role in E. coli protein export.

Bibliography

Schatz, P. J., Riggs, P. D., Jacq, A., Fath, M. J., & Beckwith, J. (1989). The secE gene encodes an integral membrane protein required for protein export in Escherichia coli. Genes & Development, 3(7), 1035–1044.

Authors 5
  1. P J Schatz (first)
  2. P D Riggs (additional)
  3. A Jacq (additional)
  4. M J Fath (additional)
  5. J Beckwith (additional)
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Dates
Type When
Created 18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited 3 years, 9 months ago (Nov. 13, 2021, 11:01 p.m.)
Indexed 2 months ago (July 2, 2025, 2:46 p.m.)
Issued 36 years, 2 months ago (July 1, 1989)
Published 36 years, 2 months ago (July 1, 1989)
Published Online 36 years, 2 months ago (July 1, 1989)
Published Print 36 years, 2 months ago (July 1, 1989)
Funders 0

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@article{Schatz_1989, title={The secE gene encodes an integral membrane protein required for protein export in Escherichia coli.}, volume={3}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.3.7.1035}, DOI={10.1101/gad.3.7.1035}, number={7}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Schatz, P J and Riggs, P D and Jacq, A and Fath, M J and Beckwith, J}, year={1989}, month=jul, pages={1035–1044} }