DOI: 10.1101/gad.3.1.85. Two transcripts from the rotund region of Drosophila show similar positional specificities in imaginal disc tissues.

Two transcripts from the rotund region of Drosophila show similar positional specificities in imaginal disc tissues.

10.1101/gad.3.1.85

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The rotund (rn) mutation in Drosophila is unique in that its phenotype is limited to the deletion of specific distal parts, though not the extremities, of all adult appendages. We have cloned the rn gene, located at cytogenetic position 84D3,4, by chromosomal walking. The functional rn unit, defined genetically by the localization of 13 noncomplementing rn alleles, covers approximately 50 kb of DNA. Despite different developmental profiles, two transcript size classes (1.7 and 5.3 kb) from this region show an indistinguishable pattern of spatial expression in the imaginal discs at the white pupa stage. There is a high correlation between the specificity of the mutant phenotype and the accumulation of transcripts in the presumptive distal regions of the cuticle-forming epithelial cells of the affected discs; it is, in fact, the first gene reported whose expression is localized with respect to the proximo distal-forming axis. For both transcripts, we have also found, uniquely in the wing disc, expression limited to the anterior region of the mesodermally derived epithelial cells, which contribute to the muscles of the thorax.

Bibliography

Agnel, M., Kerridge, S., Vola, C., & Griffin-Shea, R. (1989). Two transcripts from the rotund region of Drosophila show similar positional specificities in imaginal disc tissues. Genes & Development, 3(1), 85â95.

Authors 4

M Agnel (first)
S Kerridge (additional)
C Vola (additional)
R Griffin-Shea (additional)

References 57 Referenced 25

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Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 13, 2021, 10:50 p.m.)
Indexed	1 year, 3 months ago (May 6, 2024, 4:48 p.m.)
Issued	36 years, 8 months ago (Jan. 1, 1989)
Published	36 years, 8 months ago (Jan. 1, 1989)
Published Online	36 years, 8 months ago (Jan. 1, 1989)
Published Print	36 years, 8 months ago (Jan. 1, 1989)

Funders 0

None

BibTeX

@article{Agnel_1989, title={Two transcripts from the rotund region of Drosophila show similar positional specificities in imaginal disc tissues.}, volume={3}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.3.1.85}, DOI={10.1101/gad.3.1.85}, number={1}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Agnel, M and Kerridge, S and Vola, C and Griffin-Shea, R}, year={1989}, month=jan, pages={85–95} }

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