DOI: 10.1101/gad.242702. A cellular memory module conveys epigenetic inheritance of <i>hedgehog</i> expression during <i>Drosophila</i> wing imaginal disc development

A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development

10.1101/gad.242702

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

In Drosophila, the Trithorax-group (trxG) and Polycomb-group (PcG) proteins interact with chromosomal elements, termed Cellular Memory Modules (CMMs). By modifying chromatin, this ensures a stable heritable maintenance of the transcriptional state of developmental regulators, like the homeotic genes, that is defined embryonically. We asked whether such CMMs could also control expression of genes involved in patterning imaginal discs during larval development. Our results demonstrate that expression of the hedgehog gene, once activated, is maintained by a CMM. In addition, our experiments indicate that the switching of such CMMs to an active state during larval stages, in contrast to embryonic stages, may require specifictrans-activators. Our results suggest that the patterning of cells in particular developmental fields in the imaginal discs does not only rely on external cues from morphogens, but also depends on the previous history of the cells, as the control by CMMs ensures a preformatted gene expression pattern.

Bibliography

Maurange, C., & Paro, R. (2002). A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development. Genes & Development, 16(20), 2672â2683.

Authors 2

Cédric Maurange (first)
Renato Paro (additional)

References 62 Referenced 95

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Dates

Type	When
Created	22 years, 10 months ago (Oct. 15, 2002, 6:24 p.m.)
Deposited	3 years, 9 months ago (Nov. 15, 2021, 11:16 a.m.)
Indexed	1 month, 1 week ago (July 12, 2025, 6:50 p.m.)
Issued	22 years, 10 months ago (Oct. 15, 2002)
Published	22 years, 10 months ago (Oct. 15, 2002)
Published Online	22 years, 10 months ago (Oct. 15, 2002)
Published Print	22 years, 10 months ago (Oct. 15, 2002)

Funders 0

None

BibTeX

@article{Maurange_2002, title={A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development}, volume={16}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.242702}, DOI={10.1101/gad.242702}, number={20}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Maurange, Cédric and Paro, Renato}, year={2002}, month=oct, pages={2672–2683} }

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