DOI: 10.1101/gad.231202. Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery

Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery

10.1101/gad.231202

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

De novo chromatin assembly into regularly spaced nucleosomal arrays is essential for eukaryotic genome maintenance and inheritance. The Anti-Silencing Function 1 protein (ASF1) has been shown to be a histone chaperone, participating in DNA-replication-coupled nucleosome assembly. We show that mutations in the Drosophila asf1 gene derepress silencing at heterochromatin and that the ASF1 protein has a cell cycle-specific nuclear and cytoplasmic localization. Furthermore, using both genetic and biochemical methods, we demonstrate that ASF1 interacts with the Brahma (SWI/SNF) chromatin-remodelling complex. These findings suggest that ASF1 plays a crucial role in both chromatin assembly and SWI/SNF-mediated chromatin remodelling.

Bibliography

Moshkin, Y. M., Armstrong, J. A., Maeda, R. K., Tamkun, J. W., Verrijzer, P., Kennison, J. A., & Karch, F. (2002). Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery. Genes & Development, 16(20), 2621â2626.

Authors 7

Yuri M. Moshkin (first)
Jennifer A. Armstrong (additional)
Robert K. Maeda (additional)
John W. Tamkun (additional)
Peter Verrijzer (additional)
James A. Kennison (additional)
Francois Karch (additional)

References 31 Referenced 97

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Dates

Type	When
Created	22 years, 10 months ago (Oct. 15, 2002, 6:24 p.m.)
Deposited	3 years, 9 months ago (Nov. 15, 2021, 11:15 a.m.)
Indexed	1 month, 1 week ago (July 13, 2025, 10:48 p.m.)
Issued	22 years, 10 months ago (Oct. 15, 2002)
Published	22 years, 10 months ago (Oct. 15, 2002)
Published Online	22 years, 10 months ago (Oct. 15, 2002)
Published Print	22 years, 10 months ago (Oct. 15, 2002)

Funders 0

None

BibTeX

@article{Moshkin_2002, title={Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery}, volume={16}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.231202}, DOI={10.1101/gad.231202}, number={20}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Moshkin, Yuri M. and Armstrong, Jennifer A. and Maeda, Robert K. and Tamkun, John W. and Verrijzer, Peter and Kennison, James A. and Karch, Francois}, year={2002}, month=oct, pages={2621–2626} }

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