SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits.
10.1101/gad.2.5.517
Crossref journal-article
Cold Spring Harbor Laboratory
Genes & Development (246)
Abstract

A new gene, SCH9, was isolated from Saccharomyces cerevisiae by its ability to complement a cdc25ts mutation. Sequence analysis indicates that it encodes a 90,000-dalton protein with a carboxy-terminal domain homologous to yeast and mammalian cAMP-dependent protein kinase catalytic subunits. In addition to suppressing loss of CDC25 function, multicopy plasmids containing SCH9 suppress the growth defects of strains lacking the RAS genes, the CYR1 gene, which encodes adenylyl cyclase, and the TPK genes, which encode the cAMP-dependent protein kinase catalytic subunits. Cells lacking SCH9 grow slowly and have a prolonged G1 phase of the cell cycle. This defect is suppressed by activation of the cAMP effector pathway. We propose that SCH9 encodes a protein kinase that is part of a growth control pathway which is at least partially redundant with the cAMP pathway.

Bibliography

Toda, T., Cameron, S., Sass, P., & Wigler, M. (1988). SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes & Development, 2(5), 517–527.

Authors 4
  1. T Toda (first)
  2. S Cameron (additional)
  3. P Sass (additional)
  4. M Wigler (additional)
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Dates
Type When
Created 18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited 3 years, 9 months ago (Nov. 13, 2021, 10:48 p.m.)
Indexed 1 month, 1 week ago (July 23, 2025, 8 a.m.)
Issued 37 years, 3 months ago (May 1, 1988)
Published 37 years, 3 months ago (May 1, 1988)
Published Online 37 years, 3 months ago (May 1, 1988)
Published Print 37 years, 3 months ago (May 1, 1988)
Funders 0

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@article{Toda_1988, title={SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits.}, volume={2}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.2.5.517}, DOI={10.1101/gad.2.5.517}, number={5}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Toda, T and Cameron, S and Sass, P and Wigler, M}, year={1988}, month=may, pages={517–527} }