DOI: 10.1101/gad.182100. Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins

Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins

10.1101/gad.182100

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

Ultraviolet B (UVB) damage is recognized as the most important etiological factor in the development of skin cancer. Human papillomaviruses (HPV) have also been implicated in the disease, although the mechanism of action of these viruses remains unknown. We present evidence here that Bak protein is involved in signaling apoptosis in the skin in response to UVB damage, and that cutaneous HPV E6 proteins target and abrogate Bak function by promoting its proteolytic degradation both in vitro and in regenerated epithelium. Additionally, HPV positive skin cancers had undetectable levels of Bak in contrast to HPV negative cancers, which expressed Bak. This study supports a link between the virus and UVB in the induction of HPV-associated skin cancer and reveals a survival mechanism of virally infected cells.

Bibliography

Jackson, S., Harwood, C., Thomas, M., Banks, L., & Storey, A. (2000). Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes & Development, 14(23), 3065â3073.

Authors 5

Sarah Jackson (first)
Catherine Harwood (additional)
Miranda Thomas (additional)
Lawrence Banks (additional)
Alan Storey (additional)

References 38 Referenced 258

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{'key': '2021111419245322000_14.23.3065.2', 'first-page': '1045', 'article-title': 'Apoptosis is inversely related to necrosis and determines net growth in tumours bearing constitutively expressed myc, ras, and HPV oncogenes.', 'volume': '144', 'author': 'Arends', 'year': '1994', 'journal-title': 'Am. J. Path.'} / Am. J. Path. / Apoptosis is inversely related to necrosis and determines net growth in tumours bearing constitutively expressed myc, ras, and HPV oncogenes. by Arends (1994)
10.1016/S0360-3016(98)00065-0
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{'key': '2021111419245322000_14.23.3065.20', 'first-page': '99', 'article-title': 'Apoptosis in keratinocytes is not dependent on induction of differentiation.', 'volume': '76', 'author': 'Mitra', 'year': '1997', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Apoptosis in keratinocytes is not dependent on induction of differentiation. by Mitra (1997)
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 8 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:39 p.m.)
Indexed	1 month, 3 weeks ago (July 6, 2025, 7:21 p.m.)
Issued	24 years, 8 months ago (Dec. 1, 2000)
Published	24 years, 8 months ago (Dec. 1, 2000)
Published Online	24 years, 8 months ago (Dec. 1, 2000)
Published Print	24 years, 8 months ago (Dec. 1, 2000)

Funders 0

None

BibTeX

@article{Jackson_2000, title={Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins}, volume={14}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.182100}, DOI={10.1101/gad.182100}, number={23}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Jackson, Sarah and Harwood, Catherine and Thomas, Miranda and Banks, Lawrence and Storey, Alan}, year={2000}, month=dec, pages={3065–3073} }

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