DOI: 10.1101/gad.1774209. Midline governs axon pathfinding by coordinating expression of two major guidance systems

Midline governs axon pathfinding by coordinating expression of two major guidance systems

10.1101/gad.1774209

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

Formation of the neural network requires concerted action of multiple axon guidance systems. How neurons orchestrate expression of multiple guidance genes is poorly understood. Here, we show that Drosophila T-box protein Midline controls expression of genes encoding components of two major guidance systems: Frazzled, ROBO, and Slit. In midline mutant, expression of all these molecules are reduced, resulting in severe axon guidance defects, whereas misexpression of Midline induces their expression. Midline is present on the promoter regions of these genes, indicating that Midline controls transcription directly. We propose that Midline controls axon pathfinding through coordinating the two guidance systems.

Bibliography

Liu, Q.-X., Hiramoto, M., Ueda, H., Gojobori, T., Hiromi, Y., & Hirose, S. (2009). Midline governs axon pathfinding by coordinating expression of two major guidance systems. Genes & Development, 23(10), 1165â1170.

Authors 6

Qing-Xin Liu (first)
Masaki Hiramoto (additional)
Hitoshi Ueda (additional)
Takashi Gojobori (additional)
Yasushi Hiromi (additional)
Susumu Hirose (additional)

References 32 Referenced 28

10.1016/S0925-4773(00)00346-4
10.1016/S0092-8674(00)80803-X
10.1242/dev.118.2.401 / Development / Targeted gene expression as a means of altering cell fates and generating dominant phenotypes by Brand (1993)
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10.1016/S0896-6273(00)80154-3
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10.1002/dvdy.20076

Dates

Type	When
Created	16 years, 3 months ago (May 18, 2009, 12:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 16, 2021, 12:23 p.m.)
Indexed	1 year, 11 months ago (Sept. 13, 2023, 4:23 p.m.)
Issued	16 years, 3 months ago (May 15, 2009)
Published	16 years, 3 months ago (May 15, 2009)
Published Online	16 years, 3 months ago (May 15, 2009)
Published Print	16 years, 3 months ago (May 15, 2009)

Funders 0

None

BibTeX

@article{Liu_2009, title={Midline governs axon pathfinding by coordinating expression of two major guidance systems}, volume={23}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.1774209}, DOI={10.1101/gad.1774209}, number={10}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Liu, Qing-Xin and Hiramoto, Masaki and Ueda, Hitoshi and Gojobori, Takashi and Hiromi, Yasushi and Hirose, Susumu}, year={2009}, month=may, pages={1165–1170} }

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