Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
10.1101/gad.1424806
Crossref journal-article
Cold Spring Harbor Laboratory
Genes & Development (246)
Abstract

A decade of intensive investigation of coactivators and corepressors required for regulated actions of DNA-binding transcription factors has revealed a network of sequentially exchanged cofactor complexes that execute a series of enzymatic modifications required for regulated gene expression. These coregulator complexes possess “sensing” activities required for interpretation of multiple signaling pathways. In this review, we examine recent progress in understanding the functional consequences of “molecular sensor” and “molecular adaptor” actions of corepressor/coactivator complexes in integrating signal-dependent programs of transcriptional responses at the molecular level. This strategy imposes a temporal order for modifying programs of transcriptional regulation in response to the cellular milieu, which is used to mediate developmental/homeostatic and pathological events.

Bibliography

Rosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006). Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes & Development, 20(11), 1405–1428.

Authors 3
  1. Michael G. Rosenfeld (first)
  2. Victoria V. Lunyak (additional)
  3. Christopher K. Glass (additional)
References 255 Referenced 771
  1. 10.1074/jbc.274.27.18932
  2. 10.1016/S0092-8674(00)00169-0
  3. 10.1016/S0092-8674(02)01077-2
  4. 10.1006/bbrc.1999.1132
  5. 10.1016/S0168-9525(01)02317-4
  6. 10.1210/me.13.9.1522
  7. 10.1093/emboj/18.18.5108
  8. 10.1016/j.cell.2004.05.009
  9. 10.1038/nature01648
  10. 10.1002/1521-4141(200212)32:12<3765::AID-IMMU3765>3.0.CO;2-I
  11. 10.1128/MCB.24.1.442-453.2004
  12. 10.1016/0092-8674(95)90355-0
  13. 10.1101/gad.1342605
  14. 10.1016/S0092-8674(02)00809-7
  15. {'key': '2021111607395188000_20.11.1405.15', 'first-page': '1144', 'article-title': 'Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells.', 'volume': '11', 'author': 'Baek', 'year': '2006', 'journal-title': 'Proc. Natl. Acad. Sci.'} / Proc. Natl. Acad. Sci. / Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells. by Baek (2006)
  16. {'key': '2021111607395188000_20.11.1405.16', 'first-page': '1733', 'article-title': 'The adenovirus E1A 289R and 243R proteins inhibit the phosphorylation of p300.', 'volume': '9', 'author': 'Banerjee', 'year': '1994', 'journal-title': 'Oncogene'} / Oncogene / The adenovirus E1A 289R and 243R proteins inhibit the phosphorylation of p300. by Banerjee (1994)
  17. 10.1038/35065138
  18. 10.1016/S0092-8674(02)00798-5
  19. 10.1074/jbc.M001985200
  20. 10.1016/S0092-8674(00)80929-0
  21. 10.1016/0092-8674(95)90201-5
  22. 10.1016/S0955-0674(99)80046-5
  23. 10.1074/jbc.M110598200
  24. 10.1093/emboj/19.20.5376
  25. 10.1038/375377a0
  26. 10.1101/gad.940201 / Saccharomyces cerevisiae. Genes & Dev. / Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in by Briggs (2001)
  27. 10.1074/jbc.M307123200
  28. 10.1038/39645
  29. 10.1074/jbc.C100466200
  30. 10.1016/S0168-9525(03)00115-X
  31. 10.1002/glia.10145
  32. 10.1002/j.1460-2075.1995.tb00044.x / EMBO J. / Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. by Cavailles (1995)
  33. 10.1038/sj.onc.1206029
  34. 10.1016/S0092-8674(00)80552-8
  35. 10.1021/bi962069i
  36. 10.1126/science.281.5382.1505
  37. 10.1038/377454a0
  38. 10.1126/science.284.5423.2174
  39. 10.1038/nm972
  40. 10.1128/MCB.25.14.5965-5972.2005
  41. 10.1128/MCB.19.4.2515 / Mol. Cell. Biol. / Esa1p is an essential histone acetyltransferase required for cell cycle progression. by Clarke (1999)
  42. 10.1016/S1097-2765(02)00604-4
  43. 10.1038/sj.emboj.7600500
  44. 10.1073/pnas.160257997
  45. 10.1042/bj3420249
  46. 10.1074/jbc.C300494200
  47. 10.1101/gad.12.21.3343
  48. 10.1126/science.1109374
  49. 10.1139/bcb-77-4-265
  50. 10.1056/NEJMp048178
  51. 10.1210/er.2002-0006
  52. 10.1074/jbc.M001327200
  53. 10.1074/jbc.274.53.38225
  54. 10.1016/j.jsbmb.2004.12.015
  55. 10.1126/science.2119054
  56. 10.1101/gad.13.8.954
  57. 10.1016/j.cell.2005.04.031
  58. 10.1074/jbc.C200348200
  59. 10.1016/S0014-5793(99)00343-9
  60. 10.1016/j.cell.2005.07.003
  61. 10.1016/S1097-2765(04)00026-7
  62. 10.1016/S0960-9822(02)00924-7
  63. 10.1038/35094009
  64. 10.1016/S1097-2765(03)00014-5
  65. 10.1016/S0955-0674(03)00013-9
  66. 10.1016/j.molcel.2004.10.014
  67. 10.1038/sj.emboj.7600853
  68. 10.1073/pnas.94.7.2927
  69. 10.1093/emboj/cdf374
  70. 10.1073/pnas.0305411101
  71. 10.1101/gad.14.2.121 / Genes & Dev. / The coregulator exchange in transcriptional functions of nuclear receptors. by Glass (2000)
  72. 10.1101/gad.11.13.1640
  73. 10.1128/MCB.21.18.6091-6101.2001
  74. 10.1007/s00018-002-8527-2
  75. 10.1074/jbc.M507553200
  76. 10.1074/jbc.M001297200
  77. 10.1038/nrm1177
  78. 10.1038/42750
  79. 10.1038/387043a0
  80. 10.1101/gad.1144003
  81. 10.1016/S1043-2760(01)00527-6
  82. 10.1016/j.molcel.2004.10.010
  83. 10.1128/MCB.26.2.457-471.2006
  84. 10.1016/S0092-8674(00)80575-9
  85. 10.1128/MCB.20.17.6612-6625.2000
  86. 10.1038/377397a0
  87. 10.1016/S0092-8674(00)00034-9
  88. 10.1038/47069
  89. 10.1093/emboj/cdg219
  90. 10.1074/jbc.M007372200
  91. 10.1016/S1097-2765(02)00826-2
  92. 10.1016/S0092-8674(00)00051-9
  93. Impey S. Goodman R.H. (2001) CREB signaling—Timing is everything. Sci. STKE 2001:PE1. (10.1126/stke.2001.82.pe1)
  94. 10.1016/S0896-6273(02)00654-2
  95. 10.1210/me.15.8.1329
  96. 10.1093/nass/42.1.207
  97. 10.1126/science.288.5470.1422
  98. 10.1006/bbrc.1996.1740
  99. {'key': '2021111607395188000_20.11.1405.99', 'first-page': '1961', 'article-title': 'Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP.', 'volume': '12', 'author': 'Janknecht', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene / Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. by Janknecht (1996)
  100. 10.1126/science.1063127
  101. 10.1038/34184
  102. 10.1016/j.molimm.2004.06.039
  103. 10.1074/jbc.M410128200
  104. 10.1016/0092-8674(90)90395-U
  105. 10.1038/nm820
  106. 10.1016/j.cell.2004.11.017
  107. 10.1101/gad.1263005
  108. 10.1038/nri1703
  109. 10.1016/S0092-8674(02)00692-X
  110. 10.1073/pnas.95.21.12191
  111. 10.1016/S1097-2765(03)00450-7
  112. 10.1016/j.cell.2004.11.002
  113. 10.1038/nature03452
  114. 10.1101/gad.1331805
  115. 10.1016/S0092-8674(02)01084-X
  116. 10.1074/jbc.M002840200
  117. 10.1038/371528a0
  118. 10.1016/S1097-2765(04)00185-6
  119. 10.1073/pnas.97.3.1032
  120. 10.1074/jbc.273.27.16651
  121. 10.1126/science.1087344
  122. 10.1210/er.2007-0041
  123. 10.1038/nature04021
  124. 10.1073/pnas.0407159102
  125. 10.1016/S0960-9822(03)00432-9
  126. 10.1016/j.cell.2004.08.007
  127. 10.1016/S0300-9084(01)01236-6
  128. 10.1210/me.13.10.1686
  129. 10.1093/emboj/19.16.4342
  130. 10.1128/MCB.23.11.3763-3773.2003
  131. 10.1016/j.cell.2005.11.037
  132. 10.1161/CIRCULATIONAHA.105.537878
  133. 10.1074/jbc.M204751200
  134. 10.1093/emboj/cdf406
  135. 10.1016/j.cell.2004.09.013
  136. 10.1101/gad.1297105
  137. 10.1038/nmeth709
  138. 10.1016/j.tibs.2005.03.009
  139. 10.1016/0092-8674(95)90200-7
  140. 10.1016/j.gde.2005.01.005
  141. 10.1002/(SICI)1097-4644(19981201)71:3<429::AID-JCB11>3.0.CO;2-P
  142. 10.1016/S1097-2765(01)00242-8
  143. 10.1073/pnas.191152098
  144. 10.1101/gad.12.21.3357
  145. 10.1210/er.20.4.435
  146. 10.1210/er.20.3.321
  147. 10.1126/science.287.5456.1262
  148. 10.1016/S1097-2765(00)80028-3
  149. 10.1016/S0092-8674(03)00934-6
  150. 10.1038/nature04020
  151. 10.1002/ajmg.1320560125
  152. 10.1016/S0955-0674(98)80015-X
  153. 10.1038/nature01720
  154. 10.1016/S1097-2765(00)80145-8
  155. 10.1126/science.293.5532.1133
  156. 10.1038/sj.emboj.7600157
  157. 10.1074/jbc.273.18.10831
  158. 10.1016/S1097-2765(04)00178-9
  159. 10.1016/S0092-8674(00)80218-4
  160. 10.1073/pnas.96.5.1858
  161. 10.1016/S1097-2765(04)00054-1
  162. 10.1016/S0968-0004(97)01034-7
  163. 10.1074/jbc.C200433200
  164. 10.1016/S1097-2765(02)00548-8
  165. 10.1038/25931
  166. 10.1073/pnas.0405786101
  167. 10.1016/j.cell.2005.06.029
  168. 10.1093/hmg/8.3.387
  169. 10.1182/blood.V93.9.2771 / Blood / Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis. by Oike (1999)
  170. Olson L.E. Tollkuhn J. Krones A. Scafoglio C. Zhang J. Ohgi K.A. Taketo M.M. Kemler R. Grosschedl R. Rose D.W. (2006) A molecular logic for distinct β-catenin-dependent switching events dictating cell lineage determination. Cell, (in press).. (10.1016/j.cell.2006.02.046)
  171. 10.1016/j.molcel.2005.02.034
  172. 10.1038/nrm1680
  173. 10.1073/pnas.96.7.3652
  174. 10.1016/S0092-8674(04)00133-3
  175. 10.1016/S1097-2765(03)00477-5
  176. {'key': '2021111607395188000_20.11.1405.176', 'first-page': '245', 'article-title': 'Chromatin remodeling: Nucleosomes bulging at the seams.', 'volume': '12', 'author': 'Peterson', 'year': '2002', 'journal-title': 'Cell'} / Cell / Chromatin remodeling: Nucleosomes bulging at the seams. by Peterson (2002)
  177. 10.1038/376348a0
  178. 10.1016/S0092-8674(02)01169-8
  179. 10.1038/sj.onc.1202406
  180. 10.1128/MCB.22.24.8774-8786.2002
  181. 10.1146/annurev.physiol.66.032802.155556
  182. 10.1210/er.2002-0012
  183. 10.1016/S0092-8674(00)80463-8
  184. 10.1073/pnas.91.2.752
  185. 10.1128/MCB.25.6.2406-2418.2005
  186. 10.1038/35020506
  187. 10.1016/S1097-2765(03)00090-X
  188. 10.1101/sqb.2004.69.171
  189. 10.1038/378681a0
  190. 10.1016/S1097-2765(03)00479-9
  191. 10.1016/S0092-8674(02)00644-X
  192. 10.1038/34178
  193. 10.1016/S0092-8674(00)80317-7
  194. 10.1038/nature03354
  195. 10.1093/emboj/20.21.6071
  196. 10.1074/jbc.R100041200
  197. 10.1146/annurev.biochem.70.1.81
  198. 10.1038/nsmb1048
  199. 10.1016/0005-2787(81)90045-9 / Biochim. Biophys. Acta / A histone H4-specific methyltransferase. Properties, specificity and effects on nucleosomal histones. by Sarnow (1981)
  200. 10.1016/0092-8674(90)90397-W
  201. 10.1101/gad.973302
  202. 10.1126/science.290.5494.1127
  203. 10.1074/jbc.M003783200
  204. 10.1016/S1097-2765(05)00081-X
  205. 10.1016/S0092-8674(00)00188-4
  206. 10.1210/me.14.8.1198
  207. 10.1006/bbrc.2000.3424
  208. 10.1016/j.cell.2004.12.012
  209. 10.1016/j.molcel.2005.08.027
  210. 10.1016/S0092-8674(00)81717-1
  211. 10.1101/gad.872801
  212. 10.1016/j.cell.2004.09.037
  213. 10.1038/31701
  214. 10.1158/0008-5472.CAN-03-3207
  215. 10.1128/MCB.22.5.1298-1306.2002
  216. 10.1038/nature00883
  217. 10.1101/gad.989402
  218. 10.1126/science.277.5333.1827
  219. 10.1247/csf.15.127 / Cell Struct. Funct. / Proteasomes (multicatalytic proteinase complexes) in eukaryotic cells. by Tanaka (1990)
  220. 10.1016/S0021-9258(18)34678-7 / J. Biol. Chem. / Participation of poly(ADP-ribosyl)ation in the depression of RNA synthesis caused by treatment of mouse lymphoma cells with methylnitrosourea. by Taniguchi (1982)
  221. 10.1073/pnas.022469899
  222. 10.1128/MCB.24.8.3337-3346.2004
  223. 10.1038/42652
  224. 10.1038/nature04433
  225. 10.1101/gad.1003902
  226. 10.1074/jbc.M007864200
  227. 10.1016/S1097-2765(00)80301-9
  228. 10.1126/science.1074973
  229. 10.1038/378690a0
  230. 10.1210/me.2003-0421
  231. 10.1002/jcp.20141
  232. 10.1016/j.cmet.2006.01.002
  233. 10.1210/me.14.12.1976
  234. 10.1172/JCI200320514
  235. 10.1016/0303-7207(93)90167-I
  236. 10.1074/jbc.M308135200
  237. 10.1101/gad.9.9.1033
  238. 10.1016/S1097-2765(02)00802-X
  239. 10.1146/annurev.biochem.67.1.545
  240. 10.1016/j.molcel.2004.08.019
  241. 10.1016/j.cell.2005.03.036
  242. 10.1038/26270
  243. 10.1126/science.1065961
  244. {'key': '2021111607395188000_20.11.1405.244', 'first-page': '5389', 'article-title': 'Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification.', 'volume': '11', 'author': 'Yaciuk', 'year': '1991', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification. by Yaciuk (1991)
  245. 10.1038/nature01576
  246. 10.1016/S0092-8674(00)81165-4
  247. 10.1073/pnas.96.23.13108
  248. 10.1093/emboj/cdg120
  249. 10.1016/j.molcel.2003.08.008
  250. 10.1074/jbc.M007832200
  251. 10.1016/S1097-2765(02)00468-9
  252. 10.1016/S1097-2765(00)80066-0
  253. 10.1210/me.12.10.1594
  254. 10.1023/A:1011087910699
  255. 10.1016/j.cell.2005.12.032
Dates
Type When
Created 19 years, 2 months ago (June 1, 2006, 10:16 p.m.)
Deposited 3 years, 9 months ago (Nov. 16, 2021, 11:55 a.m.)
Indexed 9 hours, 24 minutes ago (Aug. 25, 2025, 2:23 a.m.)
Issued 19 years, 2 months ago (June 1, 2006)
Published 19 years, 2 months ago (June 1, 2006)
Published Online 19 years, 2 months ago (June 1, 2006)
Published Print 19 years, 2 months ago (June 1, 2006)
Funders 0

None

@article{Rosenfeld_2006, title={Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response}, volume={20}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.1424806}, DOI={10.1101/gad.1424806}, number={11}, journal={Genes &amp; Development}, publisher={Cold Spring Harbor Laboratory}, author={Rosenfeld, Michael G. and Lunyak, Victoria V. and Glass, Christopher K.}, year={2006}, month=jun, pages={1405–1428} }