DOI: 10.1101/gad.14.2.152. An essential role in liver development for transcription factor XBP-1

An essential role in liver development for transcription factor XBP-1

10.1101/gad.14.2.152

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP-1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.

Bibliography

Reimold, A. M., Etkin, A., Clauss, I., Perkins, A., Friend, D. S., Zhang, J., Horton, H. F., Scott, A., Orkin, S. H., Byrne, M. C., Grusby, M. J., & Glimcher, L. H. (2000). An essential role in liver development for transcription factor XBP-1. Genes & Development, 14(2), 152â157.

Authors 12

Andreas M. Reimold (first)
Amit Etkin (additional)
Isabelle Clauss (additional)
Andrew Perkins (additional)
Daniel S. Friend (additional)
John Zhang (additional)
Heidi F. Horton (additional)
Andrew Scott (additional)
Stuart H. Orkin (additional)
Michael C. Byrne (additional)
Michael J. Grusby (additional)
Laurie H. Glimcher (additional)

References 32 Referenced 439

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{'key': '2021111419175606000_14.2.152.17', 'first-page': '337', 'article-title': 'Enhanced expression of a new class of liver-enriched b-zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans.', 'volume': '9', 'author': 'Kishimoto', 'year': '1998', 'journal-title': 'Cell Growth Differ.'} / Cell Growth Differ. / Enhanced expression of a new class of liver-enriched b-zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans. by Kishimoto (1998)
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Dates

Type	When
Created	3 years, 9 months ago (Nov. 14, 2021, 10:27 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:28 p.m.)
Indexed	3 days, 19 hours ago (Aug. 26, 2025, 2:38 a.m.)
Issued	25 years, 7 months ago (Jan. 15, 2000)
Published	25 years, 7 months ago (Jan. 15, 2000)
Published Online	25 years, 7 months ago (Jan. 15, 2000)
Published Print	25 years, 7 months ago (Jan. 15, 2000)

Funders 0

None

BibTeX

@article{Reimold_2000, title={An essential role in liver development for transcription factor XBP-1}, volume={14}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.14.2.152}, DOI={10.1101/gad.14.2.152}, number={2}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Reimold, Andreas M. and Etkin, Amit and Clauss, Isabelle and Perkins, Andrew and Friend, Daniel S. and Zhang, John and Horton, Heidi F. and Scott, Andrew and Orkin, Stuart H. and Byrne, Michael C. and Grusby, Michael J. and Glimcher, Laurie H.}, year={2000}, month=jan, pages={152–157} }

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