DOI: 10.1101/gad.14.13.1589. Error-prone bypass of certain DNA lesions by the human DNA polymerase κ

Error-prone bypass of certain DNA lesions by the human DNA polymerase κ

10.1101/gad.14.13.1589

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The Escherichia coli protein DinB is a newly identified error-prone DNA polymerase. Recently, a human homolog of DinB was identified and named DINB1. We report that the DINB1gene encodes a DNA polymerase (designated polκ), which incorporates mismatched bases on a nondamaged template with a high frequency. Moreover, polκ bypasses an abasic site andN-2–acetylaminofluorene (AAF)-adduct in an error-prone manner but does not bypass a cis–syn or (6-4) thymine–thymine dimer or a cisplatin-adduct. Therefore, our results implicate an important role for polκ in the mutagenic bypass of certain types of DNA lesions.

Bibliography

Ohashi, E., Ogi, T., Kusumoto, R., Iwai, S., Masutani, C., Hanaoka, F., & Ohmori, H. (2000). Error-prone bypass of certain DNA lesions by the human DNA polymerase Îº. Genes & Development, 14(13), 1589â1594.

Authors 7

Eiji Ohashi (first)
Tomoo Ogi (additional)
Rika Kusumoto (additional)
Shigenori Iwai (additional)
Chikahide Masutani (additional)
Fumio Hanaoka (additional)
Haruo Ohmori (additional)

References 33 Referenced 217

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Dates

Type	When
Created	3 years, 9 months ago (Nov. 14, 2021, 10:33 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:33 p.m.)
Indexed	1 year ago (Aug. 8, 2024, 5:13 p.m.)
Issued	25 years, 1 month ago (July 1, 2000)
Published	25 years, 1 month ago (July 1, 2000)
Published Online	25 years, 1 month ago (July 1, 2000)
Published Print	25 years, 1 month ago (July 1, 2000)

Funders 0

None

BibTeX

@article{Ohashi_2000, title={Error-prone bypass of certain DNA lesions by the human DNA polymerase κ}, volume={14}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.14.13.1589}, DOI={10.1101/gad.14.13.1589}, number={13}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Ohashi, Eiji and Ogi, Tomoo and Kusumoto, Rika and Iwai, Shigenori and Masutani, Chikahide and Hanaoka, Fumio and Ohmori, Haruo}, year={2000}, month=jul, pages={1589–1594} }

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