DOI: 10.1101/gad.14.11.1308. The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner

The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner

10.1101/gad.14.11.1308

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The structure of chromatin regulates the genetic activity of the underlying DNA sequence. We report here that the protein encoded by the proto-oncogene DEK, which is involved in acute myelogenous leukemia, induces alterations of the superhelical density of DNA in chromatin. The change in topology is observed with chromatin but not with naked DNA and does not involve dissociation of core histones from chromatin. Moreover, these effects require histone H2A/H2B dimers in addition to histone H3/H4. We additionally tested whether the DEK protein affects DNA-utilizing processes and found that the DEK protein substantially reduces the replication efficiency of chromatin but not of naked DNA templates.

Bibliography

Alexiadis, V., Waldmann, T., Andersen, J., Mann, M., Knippers, R., & Gruss, C. (2000). The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner. Genes & Development, 14(11), 1308â1312.

Authors 6

Vassilios Alexiadis (first)
Tanja Waldmann (additional)
Jens Andersen (additional)
Matthias Mann (additional)
Rolf Knippers (additional)
Claudia Gruss (additional)

References 38 Referenced 117

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Dates

Type	When
Created	3 years, 9 months ago (Nov. 14, 2021, 10:32 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:33 p.m.)
Indexed	3 weeks, 3 days ago (Aug. 6, 2025, 9:36 a.m.)
Issued	25 years, 2 months ago (June 1, 2000)
Published	25 years, 2 months ago (June 1, 2000)
Published Online	25 years, 2 months ago (June 1, 2000)
Published Print	25 years, 2 months ago (June 1, 2000)

Funders 0

None

BibTeX

@article{Alexiadis_2000, title={The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner}, volume={14}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.14.11.1308}, DOI={10.1101/gad.14.11.1308}, number={11}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Alexiadis, Vassilios and Waldmann, Tanja and Andersen, Jens and Mann, Matthias and Knippers, Rolf and Gruss, Claudia}, year={2000}, month=jun, pages={1308–1312} }

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