DOI: 10.1101/gad.14.10.1196. The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF<sub>II</sub>30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)

The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAFII30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)–FACT complex

10.1101/gad.14.10.1196

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

We have purified and characterized a Gcn5-independent nucleosomal histone H3 HAT complex, NuA3 (NucleosomalAcetyltransferase of histone H3). Peptide sequencing of proteins from the purified NuA3 complex identified Sas3 as the catalytic HAT subunit of the complex. Sas3 is the yeast homolog of the human MOZ oncogene. Sas3 is required for both the HAT activity and the integrity of the NuA3 complex. In addition, NuA3 contains the TBP- associated factor, yTAFII30, which is also a component of the TFIID, TFIIF, and SWI/SNF complexes. Sas3 mediates interaction of the NuA3 complex with Spt16 both in vivo and in vitro. Spt16 functions as a component of the yeast CP (Cdc68/Pob3) and mammalian FACT (facilitateschromatin transcription) complexes, which are involved in transcription elongation and DNA replication. This interaction suggests that the NuA3 complex might function in concert with FACT–CP to stimulate transcription or replication elongation through nucleosomes by providing a coupled acetyltransferase activity.

Bibliography

John, S., Howe, L., Tafrov, S. T., Grant, P. A., Sternglanz, R., & Workman, J. L. (2000). The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAFII30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)âFACT complex. Genes & Development, 14(10), 1196â1208.

Authors 6

Sam John (first)
LeAnn Howe (additional)
Stefan T. Tafrov (additional)
Patrick A. Grant (additional)
Rolf Sternglanz (additional)
Jerry L. Workman (additional)

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Dates

Type	When
Created	3 years, 9 months ago (Nov. 14, 2021, 10:31 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:33 p.m.)
Indexed	2 weeks, 5 days ago (Aug. 6, 2025, 8:39 a.m.)
Issued	25 years, 3 months ago (May 15, 2000)
Published	25 years, 3 months ago (May 15, 2000)
Published Online	25 years, 3 months ago (May 15, 2000)
Published Print	25 years, 3 months ago (May 15, 2000)

Funders 0

None

BibTeX

@article{John_2000, title={The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAFII30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)–FACT complex}, volume={14}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.14.10.1196}, DOI={10.1101/gad.14.10.1196}, number={10}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={John, Sam and Howe, LeAnn and Tafrov, Stefan T. and Grant, Patrick A. and Sternglanz, Rolf and Workman, Jerry L.}, year={2000}, month=may, pages={1196–1208} }

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