DOI: 10.1101/gad.12.22.3591. Dorsoventral patterning in the <i>Drosophila</i> central nervous system: the <i>intermediate neuroblasts defective</i> homeobox gene specifies intermediate column identity

Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity

10.1101/gad.12.22.3591

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

One of the first steps in neurogenesis is the diversification of cells along the dorsoventral axis. In Drosophila the central nervous system develops from three longitudinal columns of cells: ventral cells that express the vnd/nk2 homeobox gene, intermediate cells, and dorsal cells that express the mshhomeobox gene. Here we describe a new Drosophila homeobox gene,intermediate neuroblasts defective (ind), which is expressed specifically in the intermediate column cells. ind is essential for intermediate column development: Null mutants have a transformation of intermediate to dorsal column neuroectoderm fate, and only 10% of the intermediate column neuroblasts develop. The establishment of dorsoventral column identity involves negative regulation: Vnd represses ind in the ventral column, whereas ind represses msh in the intermediate column. Vertebrate genes closely related to vnd (Nkx2.1 andNkx2.2), ind (Gsh1 and Gsh2), andmsh (Msx1 and Msx3) are expressed in corresponding ventral, intermediate, and dorsal domains during vertebrate neurogenesis, raising the possibility that dorsoventral patterning within the central nervous system is evolutionarily conserved.

Bibliography

Weiss, J. B., Von Ohlen, T., Mellerick, D. M., Dressler, G., Doe, C. Q., & Scott, M. P. (1998). Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity. Genes & Development, 12(22), 3591â3602.

Authors 6

Joseph B. Weiss (first)
Tonia Von Ohlen (additional)
Dervla M. Mellerick (additional)
Gregory Dressler (additional)
Chris Q. Doe (additional)
Matthew P. Scott (additional)

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Dates

Type	When
Created	17 years, 6 months ago (Feb. 20, 2008, 5:52 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:24 p.m.)
Indexed	4 months, 1 week ago (April 22, 2025, 6:04 p.m.)
Issued	26 years, 9 months ago (Nov. 15, 1998)
Published	26 years, 9 months ago (Nov. 15, 1998)
Published Online	26 years, 9 months ago (Nov. 15, 1998)
Published Print	26 years, 9 months ago (Nov. 15, 1998)

Funders 0

None

BibTeX

@article{Weiss_1998, title={Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity}, volume={12}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.12.22.3591}, DOI={10.1101/gad.12.22.3591}, number={22}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Weiss, Joseph B. and Von Ohlen, Tonia and Mellerick, Dervla M. and Dressler, Gregory and Doe, Chris Q. and Scott, Matthew P.}, year={1998}, month=nov, pages={3591–3602} }

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